Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications
Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of...
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8452 |
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| author | Silvia Buonvino Ilaria Arciero Sonia Melino |
| author_facet | Silvia Buonvino Ilaria Arciero Sonia Melino |
| author_sort | Silvia Buonvino |
| collection | DOAJ |
| description | Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of sulfur and selenium in biologically available forms, the restoration of iron–sulfur clusters, redox system maintenance and the mitochondrial import of 5S rRNA. Recently, the relevance of TST in metabolic diseases, such as diabetes, has been highlighted, opening the way for research on important aspects of sulfur metabolism in diabetes. This review underlines the structural and functional characteristics of TST, describing the physiological role and biomedical and biotechnological applications of this essential enzyme. |
| first_indexed | 2024-03-09T12:32:43Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:32:43Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3af992e727494776a00d526fbc550d422023-11-30T22:28:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315845210.3390/ijms23158452Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological ApplicationsSilvia Buonvino0Ilaria Arciero1Sonia Melino2Department of Chemical Sciences and Technology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, ItalyDepartment of Chemical Sciences and Technology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, ItalyDepartment of Chemical Sciences and Technology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, ItalyThiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of sulfur and selenium in biologically available forms, the restoration of iron–sulfur clusters, redox system maintenance and the mitochondrial import of 5S rRNA. Recently, the relevance of TST in metabolic diseases, such as diabetes, has been highlighted, opening the way for research on important aspects of sulfur metabolism in diabetes. This review underlines the structural and functional characteristics of TST, describing the physiological role and biomedical and biotechnological applications of this essential enzyme.https://www.mdpi.com/1422-0067/23/15/8452rhodanesehydrogen sulfidecyanideredox systemiron-sulfur clustersalpha-beta domain |
| spellingShingle | Silvia Buonvino Ilaria Arciero Sonia Melino Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications International Journal of Molecular Sciences rhodanese hydrogen sulfide cyanide redox system iron-sulfur clusters alpha-beta domain |
| title | Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications |
| title_full | Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications |
| title_fullStr | Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications |
| title_full_unstemmed | Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications |
| title_short | Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications |
| title_sort | thiosulfate cyanide sulfurtransferase a mitochondrial essential enzyme from cell metabolism to the biotechnological applications |
| topic | rhodanese hydrogen sulfide cyanide redox system iron-sulfur clusters alpha-beta domain |
| url | https://www.mdpi.com/1422-0067/23/15/8452 |
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