Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis)
Ferula communis L., subsp. communis, namely giant fennel, has extensively been used in traditional medicine for a wide range of ailments. Fresh plant materials, crude extracts and isolated components of F. communis showed a wide spectrum of in vitro and in vivo pharmacological properties including a...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-11-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | http://ijbms.mums.ac.ir/pdf_6042_87e7e41a65e8e555dc44ec4ab810457e.html |
| _version_ | 1819122318125826048 |
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| author | Maryam Akaberi Milad Iranshahy Mehrdad Iranshahi |
| author_facet | Maryam Akaberi Milad Iranshahy Mehrdad Iranshahi |
| author_sort | Maryam Akaberi |
| collection | DOAJ |
| description | Ferula communis L., subsp. communis, namely giant fennel, has extensively been used in traditional medicine for a wide range of ailments. Fresh plant materials, crude extracts and isolated components of F. communis showed a wide spectrum of in vitro and in vivo pharmacological properties including antidiabetic, antimicrobial, antiproliferative, and cytotoxic activities. The present paper, reviews the traditional uses, botany, phytochemistry, pharmacology and toxicology of F. communis in order to reveal its therapeutic potential and future research opportunities. A bibliographic literature search was conducted in different scientific databases and search engines including Scopus, Cochrane Library, Embase, Google Scholar, Pubmed, SciFinder, and Web of science. Phytochemical studies have led to the isolation of different compounds such as sesquiterpenes from F. communis. This plant has two different chemotypes, the poisonous and non-poisonous chemotypes. Each chemotype is endowed with various constituents and different activities. The poisonous chemotype exhibits anticoagulant and cytotoxic activities with sesquiterpene coumarins as major constituents, while the non-poisonous one exhibits estrogenic and cytotoxic effects with daucane sesquiterpene esters as the main compounds. In addition, although various pharmacological properties have been reported for F. communis, anti-microbial activities of the plant have been investigated in most studies. Studies revealed that F. communis exhibits different biological activities, and contains various bioactive compounds. Although, antibacterial and cytotoxic activities are the two main pharmacological effects of this plant, further studies should focus on the mechanisms underlying these actions, as well as on those biological activities that have been reported traditionally. |
| first_indexed | 2024-12-22T06:50:33Z |
| format | Article |
| id | doaj.art-3afa501967a74e878e1e5383ad3720d4 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-22T06:50:33Z |
| publishDate | 2015-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-3afa501967a74e878e1e5383ad3720d42022-12-21T18:35:09ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742015-11-011811105010626042Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis)Maryam Akaberi0Milad Iranshahy1Mehrdad Iranshahi2Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranBiotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranBiotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranFerula communis L., subsp. communis, namely giant fennel, has extensively been used in traditional medicine for a wide range of ailments. Fresh plant materials, crude extracts and isolated components of F. communis showed a wide spectrum of in vitro and in vivo pharmacological properties including antidiabetic, antimicrobial, antiproliferative, and cytotoxic activities. The present paper, reviews the traditional uses, botany, phytochemistry, pharmacology and toxicology of F. communis in order to reveal its therapeutic potential and future research opportunities. A bibliographic literature search was conducted in different scientific databases and search engines including Scopus, Cochrane Library, Embase, Google Scholar, Pubmed, SciFinder, and Web of science. Phytochemical studies have led to the isolation of different compounds such as sesquiterpenes from F. communis. This plant has two different chemotypes, the poisonous and non-poisonous chemotypes. Each chemotype is endowed with various constituents and different activities. The poisonous chemotype exhibits anticoagulant and cytotoxic activities with sesquiterpene coumarins as major constituents, while the non-poisonous one exhibits estrogenic and cytotoxic effects with daucane sesquiterpene esters as the main compounds. In addition, although various pharmacological properties have been reported for F. communis, anti-microbial activities of the plant have been investigated in most studies. Studies revealed that F. communis exhibits different biological activities, and contains various bioactive compounds. Although, antibacterial and cytotoxic activities are the two main pharmacological effects of this plant, further studies should focus on the mechanisms underlying these actions, as well as on those biological activities that have been reported traditionally.http://ijbms.mums.ac.ir/pdf_6042_87e7e41a65e8e555dc44ec4ab810457e.htmlAnticoagulantFerula communis LSesquitepene coumarinsSesquiterpenesToxicity |
| spellingShingle | Maryam Akaberi Milad Iranshahy Mehrdad Iranshahi Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis) Iranian Journal of Basic Medical Sciences Anticoagulant Ferula communis L Sesquitepene coumarins Sesquiterpenes Toxicity |
| title | Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis) |
| title_full | Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis) |
| title_fullStr | Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis) |
| title_full_unstemmed | Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis) |
| title_short | Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis) |
| title_sort | review of the traditional uses phytochemistry pharmacology and toxicology of giant fennel ferula communis l subsp communis |
| topic | Anticoagulant Ferula communis L Sesquitepene coumarins Sesquiterpenes Toxicity |
| url | http://ijbms.mums.ac.ir/pdf_6042_87e7e41a65e8e555dc44ec4ab810457e.html |
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