DNA methylation markers in obesity, metabolic syndrome, and weight loss
The fact that not all individuals exposed to the same environmental risk factors develop obesity supports the hypothesis of the existence of underlying genetic and epigenetic elements. There is suggestive evidence that environmental stimuli, such as dietary pattern, particularly during pregnancy and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-05-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2019.1595297 |
| _version_ | 1797678877518069760 |
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| author | Mirian Samblas Fermín I. Milagro Alfredo Martínez |
| author_facet | Mirian Samblas Fermín I. Milagro Alfredo Martínez |
| author_sort | Mirian Samblas |
| collection | DOAJ |
| description | The fact that not all individuals exposed to the same environmental risk factors develop obesity supports the hypothesis of the existence of underlying genetic and epigenetic elements. There is suggestive evidence that environmental stimuli, such as dietary pattern, particularly during pregnancy and early life, but also in adult life, can induce changes in DNA methylation predisposing to obesity and related comorbidities. In this context, the DNA methylation marks of each individual have emerged not only as a promising tool for the prediction, screening, diagnosis, and prognosis of obesity and metabolic syndrome features, but also for the improvement of weight loss therapies in the context of precision nutrition. The main objectives in this field are to understand the mechanisms involved in transgenerational epigenetic inheritance, and featuring the nutritional and lifestyle factors implicated in the epigenetic modifications. Likewise, DNA methylation modulation caused by diet and environment may be a target for newer therapeutic strategies concerning the prevention and treatment of metabolic diseases. |
| first_indexed | 2024-03-11T23:06:19Z |
| format | Article |
| id | doaj.art-3afa7d1a7e284b6f89f4622c690998ef |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:06:19Z |
| publishDate | 2019-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-3afa7d1a7e284b6f89f4622c690998ef2023-09-21T13:09:22ZengTaylor & Francis GroupEpigenetics1559-22941559-23082019-05-0114542144410.1080/15592294.2019.15952971595297DNA methylation markers in obesity, metabolic syndrome, and weight lossMirian Samblas0Fermín I. Milagro1Alfredo Martínez2University of NavarraUniversity of NavarraUniversity of NavarraThe fact that not all individuals exposed to the same environmental risk factors develop obesity supports the hypothesis of the existence of underlying genetic and epigenetic elements. There is suggestive evidence that environmental stimuli, such as dietary pattern, particularly during pregnancy and early life, but also in adult life, can induce changes in DNA methylation predisposing to obesity and related comorbidities. In this context, the DNA methylation marks of each individual have emerged not only as a promising tool for the prediction, screening, diagnosis, and prognosis of obesity and metabolic syndrome features, but also for the improvement of weight loss therapies in the context of precision nutrition. The main objectives in this field are to understand the mechanisms involved in transgenerational epigenetic inheritance, and featuring the nutritional and lifestyle factors implicated in the epigenetic modifications. Likewise, DNA methylation modulation caused by diet and environment may be a target for newer therapeutic strategies concerning the prevention and treatment of metabolic diseases.http://dx.doi.org/10.1080/15592294.2019.1595297epigeneticsprecision nutritiongastric surgeryenergy-restriction |
| spellingShingle | Mirian Samblas Fermín I. Milagro Alfredo Martínez DNA methylation markers in obesity, metabolic syndrome, and weight loss Epigenetics epigenetics precision nutrition gastric surgery energy-restriction |
| title | DNA methylation markers in obesity, metabolic syndrome, and weight loss |
| title_full | DNA methylation markers in obesity, metabolic syndrome, and weight loss |
| title_fullStr | DNA methylation markers in obesity, metabolic syndrome, and weight loss |
| title_full_unstemmed | DNA methylation markers in obesity, metabolic syndrome, and weight loss |
| title_short | DNA methylation markers in obesity, metabolic syndrome, and weight loss |
| title_sort | dna methylation markers in obesity metabolic syndrome and weight loss |
| topic | epigenetics precision nutrition gastric surgery energy-restriction |
| url | http://dx.doi.org/10.1080/15592294.2019.1595297 |
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