Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention
Obesity and sudden cardiac death (SCD) share common risk factors. Obesity, in and of itself, can result in the development of SCD. Numerous epidemiologic and clinical studies have demonstrated the close relationships between obesity and SCD, however, the underlying mechanisms remain incompletely und...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1044923/full |
| _version_ | 1811213942304800768 |
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| author | Yan Yao Jia Xue Bing Li |
| author_facet | Yan Yao Jia Xue Bing Li |
| author_sort | Yan Yao |
| collection | DOAJ |
| description | Obesity and sudden cardiac death (SCD) share common risk factors. Obesity, in and of itself, can result in the development of SCD. Numerous epidemiologic and clinical studies have demonstrated the close relationships between obesity and SCD, however, the underlying mechanisms remain incompletely understood. Various evidences support the significance of excess adiposity in determining the risk of SCD, including anatomical remodeling, electrical remodeling, metabolic dysfunction, autonomic imbalance. Weight reduction has improved obesity related comorbidities, and reversed abnormal cardiac remodeling. Indeed, it is still unknown whether weight loss contributes to decreased risk of SCD. Further high-quality, prospective trials are needed to strengthen our understanding on weight management and SCD. |
| first_indexed | 2024-04-12T05:54:38Z |
| format | Article |
| id | doaj.art-3afb47e7f3a2419bbbb37b42abea2e01 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T05:54:38Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-3afb47e7f3a2419bbbb37b42abea2e012022-12-22T03:45:10ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-12-011010.3389/fcell.2022.10449231044923Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and interventionYan YaoJia XueBing LiObesity and sudden cardiac death (SCD) share common risk factors. Obesity, in and of itself, can result in the development of SCD. Numerous epidemiologic and clinical studies have demonstrated the close relationships between obesity and SCD, however, the underlying mechanisms remain incompletely understood. Various evidences support the significance of excess adiposity in determining the risk of SCD, including anatomical remodeling, electrical remodeling, metabolic dysfunction, autonomic imbalance. Weight reduction has improved obesity related comorbidities, and reversed abnormal cardiac remodeling. Indeed, it is still unknown whether weight loss contributes to decreased risk of SCD. Further high-quality, prospective trials are needed to strengthen our understanding on weight management and SCD.https://www.frontiersin.org/articles/10.3389/fcell.2022.1044923/fullobesitysudden cardiac deathremodelingmetabolic dysfunctionweight management |
| spellingShingle | Yan Yao Jia Xue Bing Li Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention Frontiers in Cell and Developmental Biology obesity sudden cardiac death remodeling metabolic dysfunction weight management |
| title | Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention |
| title_full | Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention |
| title_fullStr | Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention |
| title_full_unstemmed | Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention |
| title_short | Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention |
| title_sort | obesity and sudden cardiac death prevalence pathogenesis prevention and intervention |
| topic | obesity sudden cardiac death remodeling metabolic dysfunction weight management |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1044923/full |
| work_keys_str_mv | AT yanyao obesityandsuddencardiacdeathprevalencepathogenesispreventionandintervention AT jiaxue obesityandsuddencardiacdeathprevalencepathogenesispreventionandintervention AT bingli obesityandsuddencardiacdeathprevalencepathogenesispreventionandintervention |