Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism
Abstract The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug‐resistant epilepsy secondary to Lennox‐Gastaut Syndrome (LGS) and autism spectrum disorder (ASD) tr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-10-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51173 |
| _version_ | 1819093582183661568 |
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| author | Churl‐Su Kwon Alexander J. Schupper Madeline C. Fields Lara V. Marcuse Maite La Vega‐Talbott Fedor Panov Saadi Ghatan |
| author_facet | Churl‐Su Kwon Alexander J. Schupper Madeline C. Fields Lara V. Marcuse Maite La Vega‐Talbott Fedor Panov Saadi Ghatan |
| author_sort | Churl‐Su Kwon |
| collection | DOAJ |
| description | Abstract The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug‐resistant epilepsy secondary to Lennox‐Gastaut Syndrome (LGS) and autism spectrum disorder (ASD) treated with the RNS System. Both patients have experienced 75–99% clinical seizure reductions in >1 year of follow‐up. We illustrate that children with diffuse onset, multifocal epilepsy, including frontal and thalamic circuits thought to exist in the generation of LGS seizures, can be treated with responsive neurostimulation safely and effectively, targeting thalamic networks, and avoiding palliative disconnections and resections. |
| first_indexed | 2024-12-21T23:13:48Z |
| format | Article |
| id | doaj.art-3afb520c96804f22b4d21698e31c9230 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-21T23:13:48Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-3afb520c96804f22b4d21698e31c92302022-12-21T18:46:57ZengWileyAnnals of Clinical and Translational Neurology2328-95032020-10-017102035204010.1002/acn3.51173Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autismChurl‐Su Kwon0Alexander J. Schupper1Madeline C. Fields2Lara V. Marcuse3Maite La Vega‐Talbott4Fedor Panov5Saadi Ghatan6Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USAAbstract The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug‐resistant epilepsy secondary to Lennox‐Gastaut Syndrome (LGS) and autism spectrum disorder (ASD) treated with the RNS System. Both patients have experienced 75–99% clinical seizure reductions in >1 year of follow‐up. We illustrate that children with diffuse onset, multifocal epilepsy, including frontal and thalamic circuits thought to exist in the generation of LGS seizures, can be treated with responsive neurostimulation safely and effectively, targeting thalamic networks, and avoiding palliative disconnections and resections.https://doi.org/10.1002/acn3.51173 |
| spellingShingle | Churl‐Su Kwon Alexander J. Schupper Madeline C. Fields Lara V. Marcuse Maite La Vega‐Talbott Fedor Panov Saadi Ghatan Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism Annals of Clinical and Translational Neurology |
| title | Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism |
| title_full | Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism |
| title_fullStr | Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism |
| title_full_unstemmed | Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism |
| title_short | Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism |
| title_sort | centromedian thalamic responsive neurostimulation for lennox gastaut epilepsy and autism |
| url | https://doi.org/10.1002/acn3.51173 |
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