Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease
Abstract Objectives Overactive bladder (OAB) and dyskinesia are frequent complications in patients with Parkinson’s disease (PD). However, the correlation between OAB and dyskinesia has been insufficiently explored. The purpose of this study was to examine the relationship between dyskinesia, OAB, a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-024-03578-3 |
| _version_ | 1827315897854853120 |
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| author | Hong Jin Yiheng Du Jiahui Yan Jinru Zhang Xiaoyu Cheng Chengjie Mao Jing Chen Chun-feng Liu |
| author_facet | Hong Jin Yiheng Du Jiahui Yan Jinru Zhang Xiaoyu Cheng Chengjie Mao Jing Chen Chun-feng Liu |
| author_sort | Hong Jin |
| collection | DOAJ |
| description | Abstract Objectives Overactive bladder (OAB) and dyskinesia are frequent complications in patients with Parkinson’s disease (PD). However, the correlation between OAB and dyskinesia has been insufficiently explored. The purpose of this study was to examine the relationship between dyskinesia, OAB, and clinical characteristics among individuals with PD. Methods 1338 PD patients were included in the present study. Demographic features were compared between patients with or without dyskinesia and OAB symptoms. Logistic regression was conducted on dyskinesia to screen clinically relevant factors. Overactive Bladder Symptom Score (OABSS) was further used to stratify the association between the severity of OAB and the occurrence of dyskinesia. Results This study indicates that both dyskinesia and OAB are significantly related to disease severity and cognitive status. PD patients with dyskinesia and OAB having higher UPDRS scores (p < 0.001), H-Y scores (p < 0.001), NMSQ (p < 0.001) and MoCA scores (p < 0.001), and lower MMSE scores (p < 0.001) are identified. The multivariate logistic regression confirms that disease duration (p = 0.041), LEDD (p < 0.001), UPDRSII (p < 0.001), MoCA (p = 0.024), urgency (p < 0.001), frequency (p < 0.001), and nocturia (p = 0.002) are independent risk factors for dyskinesia. Trend analysis indicates that the risk of dyskinesia significantly increases when patients exhibit moderate to severe OAB symptoms (OABSS > 5) (p < 0.001). No significant interactions were found between OABSS and age, gender, disease duration, LEDD, and NMSQ scores in different subgroups, indicating that dyskinesia is more pronounced in patients with OABSS > 5. Discussion This study provides compelling evidence supporting the strong correlation between OAB and dyskinesia in PD patients, emphasizing the presence of shared pathogenic mechanisms between these two conditions. Our findings underscore the importance of considering both OAB and dyskinesia in the clinical management of PD, investigating the intricate connections between OAB and dyskinesia could unveil valuable insights into the complex pathophysiology of PD and potentially identify novel therapeutic targets for more effective PD treatment strategies. |
| first_indexed | 2024-04-24T23:05:43Z |
| format | Article |
| id | doaj.art-3afba88e44a24773a212d98947e10ab4 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-24T23:05:43Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-3afba88e44a24773a212d98947e10ab42024-03-17T12:29:43ZengBMCBMC Neurology1471-23772024-03-012411910.1186/s12883-024-03578-3Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s diseaseHong Jin0Yiheng Du1Jiahui Yan2Jinru Zhang3Xiaoyu Cheng4Chengjie Mao5Jing Chen6Chun-feng Liu7Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow UniversityDepartment of Urology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of MedicineDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow UniversityDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow UniversityDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow UniversityDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow UniversityDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow UniversityDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow UniversityAbstract Objectives Overactive bladder (OAB) and dyskinesia are frequent complications in patients with Parkinson’s disease (PD). However, the correlation between OAB and dyskinesia has been insufficiently explored. The purpose of this study was to examine the relationship between dyskinesia, OAB, and clinical characteristics among individuals with PD. Methods 1338 PD patients were included in the present study. Demographic features were compared between patients with or without dyskinesia and OAB symptoms. Logistic regression was conducted on dyskinesia to screen clinically relevant factors. Overactive Bladder Symptom Score (OABSS) was further used to stratify the association between the severity of OAB and the occurrence of dyskinesia. Results This study indicates that both dyskinesia and OAB are significantly related to disease severity and cognitive status. PD patients with dyskinesia and OAB having higher UPDRS scores (p < 0.001), H-Y scores (p < 0.001), NMSQ (p < 0.001) and MoCA scores (p < 0.001), and lower MMSE scores (p < 0.001) are identified. The multivariate logistic regression confirms that disease duration (p = 0.041), LEDD (p < 0.001), UPDRSII (p < 0.001), MoCA (p = 0.024), urgency (p < 0.001), frequency (p < 0.001), and nocturia (p = 0.002) are independent risk factors for dyskinesia. Trend analysis indicates that the risk of dyskinesia significantly increases when patients exhibit moderate to severe OAB symptoms (OABSS > 5) (p < 0.001). No significant interactions were found between OABSS and age, gender, disease duration, LEDD, and NMSQ scores in different subgroups, indicating that dyskinesia is more pronounced in patients with OABSS > 5. Discussion This study provides compelling evidence supporting the strong correlation between OAB and dyskinesia in PD patients, emphasizing the presence of shared pathogenic mechanisms between these two conditions. Our findings underscore the importance of considering both OAB and dyskinesia in the clinical management of PD, investigating the intricate connections between OAB and dyskinesia could unveil valuable insights into the complex pathophysiology of PD and potentially identify novel therapeutic targets for more effective PD treatment strategies.https://doi.org/10.1186/s12883-024-03578-3Parkinson's diseaseDyskinesiaOveractive bladderClinical characteristics |
| spellingShingle | Hong Jin Yiheng Du Jiahui Yan Jinru Zhang Xiaoyu Cheng Chengjie Mao Jing Chen Chun-feng Liu Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease BMC Neurology Parkinson's disease Dyskinesia Overactive bladder Clinical characteristics |
| title | Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease |
| title_full | Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease |
| title_fullStr | Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease |
| title_full_unstemmed | Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease |
| title_short | Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease |
| title_sort | unraveling the interplay between dyskinesia and overactive bladder symptoms in parkinson s disease a comprehensive cohort study based on the long term follow up database of parkinson s disease |
| topic | Parkinson's disease Dyskinesia Overactive bladder Clinical characteristics |
| url | https://doi.org/10.1186/s12883-024-03578-3 |
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