Hemoglobin D is the Commonest Hemoglobinopathy in the North of Iran
Abstract Background and Objective: Normal hemoglobin (Hb) is formed of a heme group and a protein group known as globin. Globin is made of four polypeptide chains and in hemoglobinopathies, the structure of one of these four polypeptide chain becomes abnormal. Cellulose acetate method is a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Golestan University of Medical Sciences
2015-11-01
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| Series: | Medical Laboratory Journal |
| Subjects: | |
| Online Access: | http://mlj.goums.ac.ir/article-1-803-en.html |
| _version_ | 1819078003943014400 |
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| author | Hamid Reza Joshaghani Saeid Parvizi Khodaberdi Kalavi naser Behnampour Hadi Joshaghani Nader Hashemi Sahar Alijanpour |
| author_facet | Hamid Reza Joshaghani Saeid Parvizi Khodaberdi Kalavi naser Behnampour Hadi Joshaghani Nader Hashemi Sahar Alijanpour |
| author_sort | Hamid Reza Joshaghani |
| collection | DOAJ |
| description | Abstract
Background and Objective: Normal hemoglobin (Hb) is formed of a heme group and a protein group known as globin. Globin is made of four polypeptide chains and in hemoglobinopathies, the structure of one of these four polypeptide chain becomes abnormal. Cellulose acetate method is a common way to differentiate haemoglobinopathies. Inability to identify the components of Hb low concentrations and incapability to isolate all Hb types are among the disadvantages of this method. The aim of this study was to report the prevalence of hemoglobinopathies in the North of Iran by capillary electrophoresis method.
Methods: All patients with suspected hemoglobinopathies, referred by physicians for electrophoresis, have been studied in a private center in the city of Gorgan, Iran. The level of HbA2, HbA, HbF and other Hb was recorded.
Results: Overall, 725 blood samples were analyzed using the capillary method. HbE was reported in 2 patients, HbH was observed in 2 patients and Hb Barts was reported in 3 patients. Using the capillary method, among patients with the SDG area, only 4 of 38 (10.52%) had HbS and the majority of them (89.48%) had HbD.
Conclusion: HbD is the most common hemoglobinopathy in the North of Iran.
Keywords: Hemoglobinopathy; hemoglobin D; Capillary Electrophoresis; Iran |
| first_indexed | 2024-12-21T19:06:11Z |
| format | Article |
| id | doaj.art-3afd04ca8fb4404a8e305b321849a97b |
| institution | Directory Open Access Journal |
| issn | 2538-4449 |
| language | English |
| last_indexed | 2024-12-21T19:06:11Z |
| publishDate | 2015-11-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj.art-3afd04ca8fb4404a8e305b321849a97b2022-12-21T18:53:20ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492015-11-01952832Hemoglobin D is the Commonest Hemoglobinopathy in the North of IranHamid Reza Joshaghani0Saeid Parvizi1Khodaberdi Kalavi2naser Behnampour3Hadi Joshaghani4Nader Hashemi5Sahar Alijanpour6 Laboratory Science Research Center, Golestan University of Medical Sciences, Gorgan, Iran Golestan University of Medical Sciences, Gorgan, Iran Laboratory Science Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Hematology and Oncology research center, Golestan University of Medical Sciences, Gorgan, Iran Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Medical Biotechnology Laboratory Science Research Center, Golestan University of Medical Science, Gorgan, Iran department of medical genetics, Faculty of advanced medical technologies, Golestan university of medical sciences, Gorgan, Iran Abstract Background and Objective: Normal hemoglobin (Hb) is formed of a heme group and a protein group known as globin. Globin is made of four polypeptide chains and in hemoglobinopathies, the structure of one of these four polypeptide chain becomes abnormal. Cellulose acetate method is a common way to differentiate haemoglobinopathies. Inability to identify the components of Hb low concentrations and incapability to isolate all Hb types are among the disadvantages of this method. The aim of this study was to report the prevalence of hemoglobinopathies in the North of Iran by capillary electrophoresis method. Methods: All patients with suspected hemoglobinopathies, referred by physicians for electrophoresis, have been studied in a private center in the city of Gorgan, Iran. The level of HbA2, HbA, HbF and other Hb was recorded. Results: Overall, 725 blood samples were analyzed using the capillary method. HbE was reported in 2 patients, HbH was observed in 2 patients and Hb Barts was reported in 3 patients. Using the capillary method, among patients with the SDG area, only 4 of 38 (10.52%) had HbS and the majority of them (89.48%) had HbD. Conclusion: HbD is the most common hemoglobinopathy in the North of Iran. Keywords: Hemoglobinopathy; hemoglobin D; Capillary Electrophoresis; Iranhttp://mlj.goums.ac.ir/article-1-803-en.htmlhemoglobinopathyhemoglobin dcapillary electrophoresisiran |
| spellingShingle | Hamid Reza Joshaghani Saeid Parvizi Khodaberdi Kalavi naser Behnampour Hadi Joshaghani Nader Hashemi Sahar Alijanpour Hemoglobin D is the Commonest Hemoglobinopathy in the North of Iran Medical Laboratory Journal hemoglobinopathy hemoglobin d capillary electrophoresis iran |
| title | Hemoglobin D is the Commonest Hemoglobinopathy in the North of Iran |
| title_full | Hemoglobin D is the Commonest Hemoglobinopathy in the North of Iran |
| title_fullStr | Hemoglobin D is the Commonest Hemoglobinopathy in the North of Iran |
| title_full_unstemmed | Hemoglobin D is the Commonest Hemoglobinopathy in the North of Iran |
| title_short | Hemoglobin D is the Commonest Hemoglobinopathy in the North of Iran |
| title_sort | hemoglobin d is the commonest hemoglobinopathy in the north of iran |
| topic | hemoglobinopathy hemoglobin d capillary electrophoresis iran |
| url | http://mlj.goums.ac.ir/article-1-803-en.html |
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