Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain
Advanced maternal age (AMA) poses the single greatest risk to a successful pregnancy. Apart from the impact of AMA on oocyte fitness, aged female mice often display defects in normal placentation. Placental defects in turn are tightly correlated with brain and cardiovascular abnormalities. It theref...
Main Authors: | Caroline Kokorudz, Bethany N. Radford, Wendy Dean, Myriam Hemberger |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-12-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/12/1/76 |
Similar Items
-
The Trophoblast Compartment Helps Maintain Embryonic Pluripotency and Delays Differentiation towards Cardiomyocytes
by: Xiang Zhao, et al.
Published: (2023-08-01) -
Maternal effects drive intestinal development beginning in the embryonic period on the basis of maternal immune and microbial transfer in chickens
by: Haizhou Gong, et al.
Published: (2023-03-01) -
Whole-genome transcriptome and DNA methylation dynamics of pre-implantation embryos reveal progression of embryonic genome activation in buffaloes
by: Penghui Fu, et al.
Published: (2023-07-01) -
DNA methylation abnormalities induced by advanced maternal age in villi prime a high-risk state for spontaneous abortion
by: Meng Qin, et al.
Published: (2023-03-01) -
Associations between Maternal Risk Factors and Intrinsic Placental and Fetal Brain Functional Properties in Congenital Heart Disease
by: Vidya Rajagopalan, et al.
Published: (2022-12-01)