Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk Pregnancies
OBJECTIVE: The present study aims to evaluate the importance of USG findings, in estimating cytogenetic abnormality risks in pregnancies otherwise carrying low risk for aneuploidy. STUDY DESIGN: We reviewed a number of most commonly observed soft markers and structural abnormalities in pregnant wome...
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| Format: | Article |
| Language: | English |
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Medical Network
2012-04-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/227 |
| _version_ | 1797920419986014208 |
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| author | Zerrin Yılmaz Özge Özer Derya Eroğlu Filiz Yanık Feride İffet Şahin |
| author_facet | Zerrin Yılmaz Özge Özer Derya Eroğlu Filiz Yanık Feride İffet Şahin |
| author_sort | Zerrin Yılmaz |
| collection | DOAJ |
| description | OBJECTIVE: The present study aims to evaluate the importance of USG findings, in estimating cytogenetic abnormality risks in pregnancies otherwise carrying low risk for aneuploidy.
STUDY DESIGN: We reviewed a number of most commonly observed soft markers and structural abnormalities in pregnant women with low risk who underwent invasive prenatal diagnostic tests for USG abnormality in the period from January 2002 to December 2008, retrospectively. In 179 of all cases (9.95%), cytogenetic analysis was recommended because of USG abnormality.
RESULTS: 76 patients had structural abnormalities, 95 had soft markers and 8 had intra-uterine growth restriction. We detected 12 aneuploidies in fetuses with structural abnormalities and 1 aneuploidy in fetuses with soft markers.
CONCLUSION: We concluded that, although the presence or absence of soft markers can substantially modify the risk of fetal aneuploidy, one or more structural abnormalities inevitably have high risk for aneuplodies as independent factor for low-risk pregnancies. |
| first_indexed | 2024-04-10T14:00:53Z |
| format | Article |
| id | doaj.art-3affc97616f94966a929bff8354ad442 |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T14:00:53Z |
| publishDate | 2012-04-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-3affc97616f94966a929bff8354ad4422023-02-15T16:10:15ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512012-04-01181159Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk PregnanciesZerrin Yılmaz0Özge Özer1Derya Eroğlu2Filiz Yanık3Feride İffet Şahin4Baskent University Faculty of Medicine Department of Medical Genetics, AnkaraBaskent University Faculty of Medicine Department of Medical Genetics, AnkaraBaskent University Faculty of Medicine Department of Obstetrics and Gyneocology, AnkaraBaskent University Faculty of Medicine Department of Obstetrics and Gyneocology, AnkaraBaskent University Faculty of Medicine Department of Medical Genetics, AnkaraOBJECTIVE: The present study aims to evaluate the importance of USG findings, in estimating cytogenetic abnormality risks in pregnancies otherwise carrying low risk for aneuploidy. STUDY DESIGN: We reviewed a number of most commonly observed soft markers and structural abnormalities in pregnant women with low risk who underwent invasive prenatal diagnostic tests for USG abnormality in the period from January 2002 to December 2008, retrospectively. In 179 of all cases (9.95%), cytogenetic analysis was recommended because of USG abnormality. RESULTS: 76 patients had structural abnormalities, 95 had soft markers and 8 had intra-uterine growth restriction. We detected 12 aneuploidies in fetuses with structural abnormalities and 1 aneuploidy in fetuses with soft markers. CONCLUSION: We concluded that, although the presence or absence of soft markers can substantially modify the risk of fetal aneuploidy, one or more structural abnormalities inevitably have high risk for aneuplodies as independent factor for low-risk pregnancies.http://gorm.com.tr/index.php/GORM/article/view/227Aneuploidy, Fetal ultrasonography, Prenatal diagnosis |
| spellingShingle | Zerrin Yılmaz Özge Özer Derya Eroğlu Filiz Yanık Feride İffet Şahin Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk Pregnancies Gynecology Obstetrics & Reproductive Medicine Aneuploidy, Fetal ultrasonography, Prenatal diagnosis |
| title | Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk Pregnancies |
| title_full | Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk Pregnancies |
| title_fullStr | Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk Pregnancies |
| title_full_unstemmed | Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk Pregnancies |
| title_short | Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk Pregnancies |
| title_sort | importance of routine ultrasonography in detecting fetal karyotype abnormalities in low risk pregnancies |
| topic | Aneuploidy, Fetal ultrasonography, Prenatal diagnosis |
| url | http://gorm.com.tr/index.php/GORM/article/view/227 |
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