From Standard to Escalated Anticoagulant Prophylaxis in Fractured Older Adults With SARS-CoV-2 Undergoing Accelerated Orthopedic Surgery
Proximal femoral fractures in older adults are not uncommon and represent a great challenge for orthopedic surgeons because of the high risks of complications. In the COVID-19 panorama, fractures occurring in infected older adults become an even more intricate task because of concomitant metabolic d...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-10-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2020.566770/full |
| _version_ | 1828940774527467520 |
|---|---|
| author | Paolo Perazzo Riccardo Giorgino Matteo Briguglio Martina Zuffada Riccardo Accetta Laura Mangiavini Laura Mangiavini Giuseppe M. Peretti Giuseppe M. Peretti |
| author_facet | Paolo Perazzo Riccardo Giorgino Matteo Briguglio Martina Zuffada Riccardo Accetta Laura Mangiavini Laura Mangiavini Giuseppe M. Peretti Giuseppe M. Peretti |
| author_sort | Paolo Perazzo |
| collection | DOAJ |
| description | Proximal femoral fractures in older adults are not uncommon and represent a great challenge for orthopedic surgeons because of the high risks of complications. In the COVID-19 panorama, fractures occurring in infected older adults become an even more intricate task because of concomitant metabolic derangements due to SARS-CoV-2. Multidisciplinary protocols are mandatory and pharmacological treatment in infected patients should be tailored. Regrettably, the spread of the virus in northern Italy, has been faster than scientific progress in characterizing the disease and many hospitals have had to manage the symptoms on a daily clinical bases. Our Italian hospital in the region of Lombardy, which has been the epicenter of the Italian pandemic, has admitted sixteen patients with fractured femurs in March and April 2020. The first seven patients were treated with the antithrombotic prophylaxis of a single daily dose of low-molecular-weight heparin, but we observed the highest prevalence of deaths from cardiovascular complications (four deaths). By doubling the daily dose of anticoagulants in the subsequent patients, we observed a reduction in the incidence of death (one death out of nine). Controversies exist about the surgical treatment of fractures in older adults during this pandemic. However, we have observed an increased survival after fall trauma in infected older adults if treated with high doses of anticoagulant. Although not being statistically significant, our results are in line with the current knowledge of the pathophysiology of SARS-CoV-2 infection, but more studies should be shared about the efficacy and dosage of anticoagulants in traumatic injuries of the elderly. |
| first_indexed | 2024-12-14T03:25:46Z |
| format | Article |
| id | doaj.art-3b008277afa04b52ab8a652535dec871 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-14T03:25:46Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3b008277afa04b52ab8a652535dec8712022-12-21T23:18:53ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-10-01710.3389/fmed.2020.566770566770From Standard to Escalated Anticoagulant Prophylaxis in Fractured Older Adults With SARS-CoV-2 Undergoing Accelerated Orthopedic SurgeryPaolo Perazzo0Riccardo Giorgino1Matteo Briguglio2Martina Zuffada3Riccardo Accetta4Laura Mangiavini5Laura Mangiavini6Giuseppe M. Peretti7Giuseppe M. Peretti8Intensive Care Unit, IRCCS Orthopedic Institute Galeazzi, Milan, ItalyOrthopedics and Traumatology, University of Milan, Milan, ItalyIRCCS Orthopedic Institute Galeazzi, Milan, ItalyOrthopedics and Traumatology, University of Milan, Milan, ItalyTraumatology Unit, IRCCS Orthopedic Institute Galeazzi, Milan, ItalyRegenerative and Reconstructive Unit, IRCCS Orthopedic Institute Galeazzi, Milan, ItalyDepartment of Biomedical Sciences for Health, University of Milan, Milan, ItalyRegenerative and Reconstructive Unit, IRCCS Orthopedic Institute Galeazzi, Milan, ItalyDepartment of Biomedical Sciences for Health, University of Milan, Milan, ItalyProximal femoral fractures in older adults are not uncommon and represent a great challenge for orthopedic surgeons because of the high risks of complications. In the COVID-19 panorama, fractures occurring in infected older adults become an even more intricate task because of concomitant metabolic derangements due to SARS-CoV-2. Multidisciplinary protocols are mandatory and pharmacological treatment in infected patients should be tailored. Regrettably, the spread of the virus in northern Italy, has been faster than scientific progress in characterizing the disease and many hospitals have had to manage the symptoms on a daily clinical bases. Our Italian hospital in the region of Lombardy, which has been the epicenter of the Italian pandemic, has admitted sixteen patients with fractured femurs in March and April 2020. The first seven patients were treated with the antithrombotic prophylaxis of a single daily dose of low-molecular-weight heparin, but we observed the highest prevalence of deaths from cardiovascular complications (four deaths). By doubling the daily dose of anticoagulants in the subsequent patients, we observed a reduction in the incidence of death (one death out of nine). Controversies exist about the surgical treatment of fractures in older adults during this pandemic. However, we have observed an increased survival after fall trauma in infected older adults if treated with high doses of anticoagulant. Although not being statistically significant, our results are in line with the current knowledge of the pathophysiology of SARS-CoV-2 infection, but more studies should be shared about the efficacy and dosage of anticoagulants in traumatic injuries of the elderly.https://www.frontiersin.org/article/10.3389/fmed.2020.566770/fullfemoral fracturesanticoagulantslow-molecular-weight heparinCOVID-19 drug treatmentSARS-CoV-2 |
| spellingShingle | Paolo Perazzo Riccardo Giorgino Matteo Briguglio Martina Zuffada Riccardo Accetta Laura Mangiavini Laura Mangiavini Giuseppe M. Peretti Giuseppe M. Peretti From Standard to Escalated Anticoagulant Prophylaxis in Fractured Older Adults With SARS-CoV-2 Undergoing Accelerated Orthopedic Surgery Frontiers in Medicine femoral fractures anticoagulants low-molecular-weight heparin COVID-19 drug treatment SARS-CoV-2 |
| title | From Standard to Escalated Anticoagulant Prophylaxis in Fractured Older Adults With SARS-CoV-2 Undergoing Accelerated Orthopedic Surgery |
| title_full | From Standard to Escalated Anticoagulant Prophylaxis in Fractured Older Adults With SARS-CoV-2 Undergoing Accelerated Orthopedic Surgery |
| title_fullStr | From Standard to Escalated Anticoagulant Prophylaxis in Fractured Older Adults With SARS-CoV-2 Undergoing Accelerated Orthopedic Surgery |
| title_full_unstemmed | From Standard to Escalated Anticoagulant Prophylaxis in Fractured Older Adults With SARS-CoV-2 Undergoing Accelerated Orthopedic Surgery |
| title_short | From Standard to Escalated Anticoagulant Prophylaxis in Fractured Older Adults With SARS-CoV-2 Undergoing Accelerated Orthopedic Surgery |
| title_sort | from standard to escalated anticoagulant prophylaxis in fractured older adults with sars cov 2 undergoing accelerated orthopedic surgery |
| topic | femoral fractures anticoagulants low-molecular-weight heparin COVID-19 drug treatment SARS-CoV-2 |
| url | https://www.frontiersin.org/article/10.3389/fmed.2020.566770/full |
| work_keys_str_mv | AT paoloperazzo fromstandardtoescalatedanticoagulantprophylaxisinfracturedolderadultswithsarscov2undergoingacceleratedorthopedicsurgery AT riccardogiorgino fromstandardtoescalatedanticoagulantprophylaxisinfracturedolderadultswithsarscov2undergoingacceleratedorthopedicsurgery AT matteobriguglio fromstandardtoescalatedanticoagulantprophylaxisinfracturedolderadultswithsarscov2undergoingacceleratedorthopedicsurgery AT martinazuffada fromstandardtoescalatedanticoagulantprophylaxisinfracturedolderadultswithsarscov2undergoingacceleratedorthopedicsurgery AT riccardoaccetta fromstandardtoescalatedanticoagulantprophylaxisinfracturedolderadultswithsarscov2undergoingacceleratedorthopedicsurgery AT lauramangiavini fromstandardtoescalatedanticoagulantprophylaxisinfracturedolderadultswithsarscov2undergoingacceleratedorthopedicsurgery AT lauramangiavini fromstandardtoescalatedanticoagulantprophylaxisinfracturedolderadultswithsarscov2undergoingacceleratedorthopedicsurgery AT giuseppemperetti fromstandardtoescalatedanticoagulantprophylaxisinfracturedolderadultswithsarscov2undergoingacceleratedorthopedicsurgery AT giuseppemperetti fromstandardtoescalatedanticoagulantprophylaxisinfracturedolderadultswithsarscov2undergoingacceleratedorthopedicsurgery |