A case of immunotactoid glomerulopathy with false-negative IgG staining
Abstract Background Immunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by microtubular deposits. Immunofluorescence findings are necessary to differentiate ITG from other proliferative glomerular diseases. The characteristic tubular structure on electron microscopy is esse...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-06-01
|
| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-018-0931-4 |
| _version_ | 1819093253140512768 |
|---|---|
| author | Shuma Hirashio Takahiro Arima Ayaka Satoh Kouichi Mandai Shigeo Hara Takao Masaki |
| author_facet | Shuma Hirashio Takahiro Arima Ayaka Satoh Kouichi Mandai Shigeo Hara Takao Masaki |
| author_sort | Shuma Hirashio |
| collection | DOAJ |
| description | Abstract Background Immunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by microtubular deposits. Immunofluorescence findings are necessary to differentiate ITG from other proliferative glomerular diseases. The characteristic tubular structure on electron microscopy is essential for a definitive diagnosis, and the diameter of the structure has been traditionally used for differentiating between ITG and other types of glomerulonephritis with organized deposits. In recent years, the disease concept of monoclonal gammopathy of renal significance, which is associated with M protein produced by plasma cell tumors, has been proposed. Case presentation This was a peculiar case of ITG with underlying monoclonal gammopathy in which IgG showed a false-negative result with immunofluorescence using frozen sections. Additional examinations using a different clone of the anti-IgG antibody revealed typical IgG staining. C4d was strongly positive, consistent with immune complex type glomerulonephritis. Conclusions This case highlights unusual features of ITG, and provides a practical hint to avoid a diagnostic pitfall. |
| first_indexed | 2024-12-21T23:08:34Z |
| format | Article |
| id | doaj.art-3b00951460b84a86bc129af1a38ad31d |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-21T23:08:34Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-3b00951460b84a86bc129af1a38ad31d2022-12-21T18:47:06ZengBMCBMC Nephrology1471-23692018-06-011911510.1186/s12882-018-0931-4A case of immunotactoid glomerulopathy with false-negative IgG stainingShuma Hirashio0Takahiro Arima1Ayaka Satoh2Kouichi Mandai3Shigeo Hara4Takao Masaki5Department of Nephrology, Hiroshima University HospitalDepartment of Nephrology, National Hospital Organization Higashihiroshima Medical CenterDepartment of Nephrology, National Hospital Organization Higashihiroshima Medical CenterDepartment of Diagnostic Pathology, National Hospital Organization Higashihiroshima Medical CenterDepartment of Diagnostic Pathology, Kobe University Graduate School of MedicineDepartment of Nephrology, Hiroshima University HospitalAbstract Background Immunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by microtubular deposits. Immunofluorescence findings are necessary to differentiate ITG from other proliferative glomerular diseases. The characteristic tubular structure on electron microscopy is essential for a definitive diagnosis, and the diameter of the structure has been traditionally used for differentiating between ITG and other types of glomerulonephritis with organized deposits. In recent years, the disease concept of monoclonal gammopathy of renal significance, which is associated with M protein produced by plasma cell tumors, has been proposed. Case presentation This was a peculiar case of ITG with underlying monoclonal gammopathy in which IgG showed a false-negative result with immunofluorescence using frozen sections. Additional examinations using a different clone of the anti-IgG antibody revealed typical IgG staining. C4d was strongly positive, consistent with immune complex type glomerulonephritis. Conclusions This case highlights unusual features of ITG, and provides a practical hint to avoid a diagnostic pitfall.http://link.springer.com/article/10.1186/s12882-018-0931-4Immunotactoid glomerulopathyFalse-negativeMonoclonal gammopathy of undetermined significanceMonoclonal gammopathy of renal significance |
| spellingShingle | Shuma Hirashio Takahiro Arima Ayaka Satoh Kouichi Mandai Shigeo Hara Takao Masaki A case of immunotactoid glomerulopathy with false-negative IgG staining BMC Nephrology Immunotactoid glomerulopathy False-negative Monoclonal gammopathy of undetermined significance Monoclonal gammopathy of renal significance |
| title | A case of immunotactoid glomerulopathy with false-negative IgG staining |
| title_full | A case of immunotactoid glomerulopathy with false-negative IgG staining |
| title_fullStr | A case of immunotactoid glomerulopathy with false-negative IgG staining |
| title_full_unstemmed | A case of immunotactoid glomerulopathy with false-negative IgG staining |
| title_short | A case of immunotactoid glomerulopathy with false-negative IgG staining |
| title_sort | case of immunotactoid glomerulopathy with false negative igg staining |
| topic | Immunotactoid glomerulopathy False-negative Monoclonal gammopathy of undetermined significance Monoclonal gammopathy of renal significance |
| url | http://link.springer.com/article/10.1186/s12882-018-0931-4 |
| work_keys_str_mv | AT shumahirashio acaseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT takahiroarima acaseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT ayakasatoh acaseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT kouichimandai acaseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT shigeohara acaseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT takaomasaki acaseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT shumahirashio caseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT takahiroarima caseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT ayakasatoh caseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT kouichimandai caseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT shigeohara caseofimmunotactoidglomerulopathywithfalsenegativeiggstaining AT takaomasaki caseofimmunotactoidglomerulopathywithfalsenegativeiggstaining |