Determination of metabolite of nicergoline in human plasma by high-performance liquid chromatography and its application in pharmacokinetic studies

Determination of metabolite of nicergoline in human plasma by high-performance liquid chromatography and its application in pharmacokinetic studies

A fast, simple and sensitive high performance liquid chromatographic (HPLC) method has been developed for determination of 10Î±-methoxy-6-methyl ergoline-8Î²-methanol (MDL, a main metabolite of nicergoline) in human plasma. One-step liquidâliquid extraction (LLE) with diethyl ether was employed as t...

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Bibliographic Details
Main Authors:	Rong Zheng, Yi-Hong Wu, De-Xi Jiang, Dan Zhang
Format:	Article
Language:	English
Published:	Elsevier 2012-02-01
Series:	Journal of Pharmaceutical Analysis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095177911000323

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