1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
1,8-cineole (Eucalyptol), a naturally occurring compound derived from botanical sources such as eucalyptus, rosemary, and camphor laurel, has a long history of use in traditional medicine and exhibits an array of biological properties, including anti-inflammatory, antioxidant, antimicrobial, broncho...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223012659 |
| _version_ | 1797660564838678528 |
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| author | Cosima C. Hoch Julie Petry Lena Griesbaum Tobias Weiser Kathrin Werner Michael Ploch Admar Verschoor Gabriele Multhoff Ali Bashiri Dezfouli Barbara Wollenberg |
| author_facet | Cosima C. Hoch Julie Petry Lena Griesbaum Tobias Weiser Kathrin Werner Michael Ploch Admar Verschoor Gabriele Multhoff Ali Bashiri Dezfouli Barbara Wollenberg |
| author_sort | Cosima C. Hoch |
| collection | DOAJ |
| description | 1,8-cineole (Eucalyptol), a naturally occurring compound derived from botanical sources such as eucalyptus, rosemary, and camphor laurel, has a long history of use in traditional medicine and exhibits an array of biological properties, including anti-inflammatory, antioxidant, antimicrobial, bronchodilatory, analgesic, and pro-apoptotic effects. Recent evidence has also indicated its potential role in managing conditions such as Alzheimer's disease, neuropathic pain, and cancer. This review spotlights the health advantages of 1,8-cineole, as demonstrated in clinical trials involving patients with respiratory disorders, including chronic obstructive pulmonary disease, asthma, bronchitis, and rhinosinusitis. In addition, we shed light on potential therapeutic applications of 1,8-cineole in various conditions, such as depression, epilepsy, peptic ulcer disease, diarrhea, cardiac-related heart diseases, and diabetes mellitus. A comprehensive understanding of 1,8-cineole’s pharmacodynamics and safety aspects as well as developing effective formulations, might help to leverage its therapeutic value. This thorough review sets the stage for future research on diverse health benefits and potential uses of 1,8-cineole in tackling complex medical conditions. |
| first_indexed | 2024-03-11T18:31:44Z |
| format | Article |
| id | doaj.art-3b040ac9cc8042ac8528cbf2cfc0e9e3 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T18:31:44Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-3b040ac9cc8042ac8528cbf2cfc0e9e32023-10-13T11:02:43ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-11-011671154671,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseasesCosima C. Hoch0Julie Petry1Lena Griesbaum2Tobias Weiser3Kathrin Werner4Michael Ploch5Admar Verschoor6Gabriele Multhoff7Ali Bashiri Dezfouli8Barbara Wollenberg9Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Technical University of Munich (TUM), 81675 Munich, GermanyDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Technical University of Munich (TUM), 81675 Munich, GermanyDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Technical University of Munich (TUM), 81675 Munich, GermanyDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Technical University of Munich (TUM), 81675 Munich, GermanyDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Technical University of Munich (TUM), 81675 Munich, GermanyCassella-med GmbH & Co. KG, 50670 Cologne, GermanyDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Technical University of Munich (TUM), 81675 Munich, GermanyCentral Institute for Translational Cancer Research, Technical University of Munich (TranslaTUM), Department of Radiation Oncology, Klinikum rechts der Isar, 81675 Munich, GermanyDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany; Central Institute for Translational Cancer Research, Technical University of Munich (TranslaTUM), Department of Radiation Oncology, Klinikum rechts der Isar, 81675 Munich, GermanyDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany; Correspondence to: Department of Otolaryngology, Head and Neck Surgery. School of Medicine, Technical University of Munich (TUM), Ismaningerstrasse 22, 81675 Munich, Germany.1,8-cineole (Eucalyptol), a naturally occurring compound derived from botanical sources such as eucalyptus, rosemary, and camphor laurel, has a long history of use in traditional medicine and exhibits an array of biological properties, including anti-inflammatory, antioxidant, antimicrobial, bronchodilatory, analgesic, and pro-apoptotic effects. Recent evidence has also indicated its potential role in managing conditions such as Alzheimer's disease, neuropathic pain, and cancer. This review spotlights the health advantages of 1,8-cineole, as demonstrated in clinical trials involving patients with respiratory disorders, including chronic obstructive pulmonary disease, asthma, bronchitis, and rhinosinusitis. In addition, we shed light on potential therapeutic applications of 1,8-cineole in various conditions, such as depression, epilepsy, peptic ulcer disease, diarrhea, cardiac-related heart diseases, and diabetes mellitus. A comprehensive understanding of 1,8-cineole’s pharmacodynamics and safety aspects as well as developing effective formulations, might help to leverage its therapeutic value. This thorough review sets the stage for future research on diverse health benefits and potential uses of 1,8-cineole in tackling complex medical conditions.http://www.sciencedirect.com/science/article/pii/S07533322230126591,8-cineoleEucalyptolRespiratory disordersAnti-inflammatory activityAntimicrobialAntioxidant |
| spellingShingle | Cosima C. Hoch Julie Petry Lena Griesbaum Tobias Weiser Kathrin Werner Michael Ploch Admar Verschoor Gabriele Multhoff Ali Bashiri Dezfouli Barbara Wollenberg 1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases Biomedicine & Pharmacotherapy 1,8-cineole Eucalyptol Respiratory disorders Anti-inflammatory activity Antimicrobial Antioxidant |
| title | 1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases |
| title_full | 1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases |
| title_fullStr | 1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases |
| title_full_unstemmed | 1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases |
| title_short | 1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases |
| title_sort | 1 8 cineole eucalyptol a versatile phytochemical with therapeutic applications across multiple diseases |
| topic | 1,8-cineole Eucalyptol Respiratory disorders Anti-inflammatory activity Antimicrobial Antioxidant |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223012659 |
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