Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male Rats
Introduction & Objectives: Peganum harmala from the Jigo Phalluses family has compounds such as: alkaloid,saponine steroid and lignin which is used as a traditional medicine witht antibacterial, anti tumor, inhibition of MAO enzyme, and stimulation of the nerve system. It also serves as a modula...
| Main Authors: | , , |
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| Format: | Article |
| Language: | fas |
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Yasuj University Of Medical Sciences
2010-01-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-416&slc_lang=en&sid=1 |
| _version_ | 1797991878992330752 |
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| author | E HOssini H Sadeghi A Daneshi |
| author_facet | E HOssini H Sadeghi A Daneshi |
| author_sort | E HOssini |
| collection | DOAJ |
| description | Introduction & Objectives: Peganum harmala from the Jigo Phalluses family has compounds such as: alkaloid,saponine steroid and lignin which is used as a traditional medicine witht antibacterial, anti tumor, inhibition of MAO enzyme, and stimulation of the nerve system. It also serves as a modulator to endocrine activities. The aim of the present study was to evaluate the effect of the hydro-alcoholic extract of Peganum harmala on plasma levels of pituitary-thyroid’s hormones of adult rats.
Materials & Methods: In this experimental study, which was conducted at Yasuj University of Medical sciences in 2009, 50 adult Mala rats with the approximate weight of 260+30 grams were divided into 5 groups: the control group, the sham group, and 3 experimental groups. The control group did not take any medicine. The sham group received 1 mL of distilled water daily for 17 consecutive days. The experimental groups took 90 mg/kg, 180mg/kg, or 270 mg/kg of Peganum harmala extract daily respectively for 17 consecutive days.
In the 18th day, by collecting the blood samples of the animals, plasma level of TSH, T4, and T3 was measured using radioimmunoassay method. Collected data were analyzed using SPSS software.
Results: This study revealed that the minimum and maximum dose of the Peganum harmala extract reduces the TSH level and average and maximum dose of the extract significantly reduces the level of T4 and T3 in rats.
Conclusion: results of this study indicate that by further study the Peganum harmala extract might be used for treatment hyperthyroidism. However further study is needed to explore this concept. |
| first_indexed | 2024-04-11T08:58:09Z |
| format | Article |
| id | doaj.art-3b04ab46ad8f43e19fdc1f29bb5308d2 |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-11T08:58:09Z |
| publishDate | 2010-01-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-3b04ab46ad8f43e19fdc1f29bb5308d22022-12-22T04:32:51ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142010-01-011442330Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male RatsE HOssini0H Sadeghi1A Daneshi2 Introduction & Objectives: Peganum harmala from the Jigo Phalluses family has compounds such as: alkaloid,saponine steroid and lignin which is used as a traditional medicine witht antibacterial, anti tumor, inhibition of MAO enzyme, and stimulation of the nerve system. It also serves as a modulator to endocrine activities. The aim of the present study was to evaluate the effect of the hydro-alcoholic extract of Peganum harmala on plasma levels of pituitary-thyroid’s hormones of adult rats. Materials & Methods: In this experimental study, which was conducted at Yasuj University of Medical sciences in 2009, 50 adult Mala rats with the approximate weight of 260+30 grams were divided into 5 groups: the control group, the sham group, and 3 experimental groups. The control group did not take any medicine. The sham group received 1 mL of distilled water daily for 17 consecutive days. The experimental groups took 90 mg/kg, 180mg/kg, or 270 mg/kg of Peganum harmala extract daily respectively for 17 consecutive days. In the 18th day, by collecting the blood samples of the animals, plasma level of TSH, T4, and T3 was measured using radioimmunoassay method. Collected data were analyzed using SPSS software. Results: This study revealed that the minimum and maximum dose of the Peganum harmala extract reduces the TSH level and average and maximum dose of the extract significantly reduces the level of T4 and T3 in rats. Conclusion: results of this study indicate that by further study the Peganum harmala extract might be used for treatment hyperthyroidism. However further study is needed to explore this concept.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-416&slc_lang=en&sid=1TSH T4 T3 Peganum Harmala |
| spellingShingle | E HOssini H Sadeghi A Daneshi Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male Rats Armaghane Danesh Bimonthly Journal TSH T4 T3 Peganum Harmala |
| title | Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male Rats |
| title_full | Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male Rats |
| title_fullStr | Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male Rats |
| title_full_unstemmed | Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male Rats |
| title_short | Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male Rats |
| title_sort | evaluation of hydro alcoholic extract of peganum harmala on pituitary thyroid hormones in adult male rats |
| topic | TSH T4 T3 Peganum Harmala |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-416&slc_lang=en&sid=1 |
| work_keys_str_mv | AT ehossini evaluationofhydroalcoholicextractofpeganumharmalaonpituitarythyroidhormonesinadultmalerats AT hsadeghi evaluationofhydroalcoholicextractofpeganumharmalaonpituitarythyroidhormonesinadultmalerats AT adaneshi evaluationofhydroalcoholicextractofpeganumharmalaonpituitarythyroidhormonesinadultmalerats |