Antidepressant therapy in patients with cardiovascular diseases

Depression is the most common form of mental illness in patients with cardiovascular diseases (CVD). Depression and CVD can worsen the clinical and dynamic characteristics of each other. The timely detection and adequate psychopharmacotherapy of depressive states in patients with CVD are of great cl...

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Main Authors: V. E. Medvedev, E. A. Korovyakova, V. I. Frolova, E. V. Gushanskaya
Format: Article
Language:Russian
Published: IMA-PRESS LLC 2019-03-01
Series:Неврология, нейропсихиатрия, психосоматика
Subjects:
Online Access:https://nnp.ima-press.net/nnp/article/view/1058
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author V. E. Medvedev
E. A. Korovyakova
V. I. Frolova
E. V. Gushanskaya
author_facet V. E. Medvedev
E. A. Korovyakova
V. I. Frolova
E. V. Gushanskaya
author_sort V. E. Medvedev
collection DOAJ
description Depression is the most common form of mental illness in patients with cardiovascular diseases (CVD). Depression and CVD can worsen the clinical and dynamic characteristics of each other. The timely detection and adequate psychopharmacotherapy of depressive states in patients with CVD are of great clinical, therapeutic, and prognostic importance. Anti-antidepressant therapy promotes a more pronounced somatic stabilizing effect in patients with CVD. Adverse events to the use of antidepressants in patients with CVD may be associated with their negative effect on the hepatic cytochrome CYP450 isoenzymes involved in the metabolism of various drugs. The authors' own data of clinical psychopharmacotherapeutic studies and the results of meta-analyses indicate the high efficiency and good tolerability of agomelatine, an antidepressant with an innovative mechanism of action, in a wide range of patients
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spelling doaj.art-3b0744c624f94f768d2a6b2a1d2fb2b12024-10-17T16:15:25ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422019-03-0111113114010.14412/2074-2711-2019-1-131-140832Antidepressant therapy in patients with cardiovascular diseasesV. E. Medvedev0E. A. Korovyakova1V. I. Frolova2E. V. Gushanskaya3Medical Institute, Peoples' Friendship University of RussiaMedical Institute, Peoples' Friendship University of RussiaMedical Institute, Peoples' Friendship University of RussiaMedical Institute, Peoples' Friendship University of RussiaDepression is the most common form of mental illness in patients with cardiovascular diseases (CVD). Depression and CVD can worsen the clinical and dynamic characteristics of each other. The timely detection and adequate psychopharmacotherapy of depressive states in patients with CVD are of great clinical, therapeutic, and prognostic importance. Anti-antidepressant therapy promotes a more pronounced somatic stabilizing effect in patients with CVD. Adverse events to the use of antidepressants in patients with CVD may be associated with their negative effect on the hepatic cytochrome CYP450 isoenzymes involved in the metabolism of various drugs. The authors' own data of clinical psychopharmacotherapeutic studies and the results of meta-analyses indicate the high efficiency and good tolerability of agomelatine, an antidepressant with an innovative mechanism of action, in a wide range of patientshttps://nnp.ima-press.net/nnp/article/view/1058cardiovascular diseasedepressiondepressionagomelatine
spellingShingle V. E. Medvedev
E. A. Korovyakova
V. I. Frolova
E. V. Gushanskaya
Antidepressant therapy in patients with cardiovascular diseases
Неврология, нейропсихиатрия, психосоматика
cardiovascular disease
depression
depression
agomelatine
title Antidepressant therapy in patients with cardiovascular diseases
title_full Antidepressant therapy in patients with cardiovascular diseases
title_fullStr Antidepressant therapy in patients with cardiovascular diseases
title_full_unstemmed Antidepressant therapy in patients with cardiovascular diseases
title_short Antidepressant therapy in patients with cardiovascular diseases
title_sort antidepressant therapy in patients with cardiovascular diseases
topic cardiovascular disease
depression
depression
agomelatine
url https://nnp.ima-press.net/nnp/article/view/1058
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AT vifrolova antidepressanttherapyinpatientswithcardiovasculardiseases
AT evgushanskaya antidepressanttherapyinpatientswithcardiovasculardiseases