Antidepressant therapy in patients with cardiovascular diseases
Depression is the most common form of mental illness in patients with cardiovascular diseases (CVD). Depression and CVD can worsen the clinical and dynamic characteristics of each other. The timely detection and adequate psychopharmacotherapy of depressive states in patients with CVD are of great cl...
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Format: | Article |
Language: | Russian |
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IMA-PRESS LLC
2019-03-01
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Series: | Неврология, нейропсихиатрия, психосоматика |
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Online Access: | https://nnp.ima-press.net/nnp/article/view/1058 |
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author | V. E. Medvedev E. A. Korovyakova V. I. Frolova E. V. Gushanskaya |
author_facet | V. E. Medvedev E. A. Korovyakova V. I. Frolova E. V. Gushanskaya |
author_sort | V. E. Medvedev |
collection | DOAJ |
description | Depression is the most common form of mental illness in patients with cardiovascular diseases (CVD). Depression and CVD can worsen the clinical and dynamic characteristics of each other. The timely detection and adequate psychopharmacotherapy of depressive states in patients with CVD are of great clinical, therapeutic, and prognostic importance. Anti-antidepressant therapy promotes a more pronounced somatic stabilizing effect in patients with CVD. Adverse events to the use of antidepressants in patients with CVD may be associated with their negative effect on the hepatic cytochrome CYP450 isoenzymes involved in the metabolism of various drugs. The authors' own data of clinical psychopharmacotherapeutic studies and the results of meta-analyses indicate the high efficiency and good tolerability of agomelatine, an antidepressant with an innovative mechanism of action, in a wide range of patients |
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format | Article |
id | doaj.art-3b0744c624f94f768d2a6b2a1d2fb2b1 |
institution | Directory Open Access Journal |
issn | 2074-2711 2310-1342 |
language | Russian |
last_indexed | 2025-02-18T20:02:10Z |
publishDate | 2019-03-01 |
publisher | IMA-PRESS LLC |
record_format | Article |
series | Неврология, нейропсихиатрия, психосоматика |
spelling | doaj.art-3b0744c624f94f768d2a6b2a1d2fb2b12024-10-17T16:15:25ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422019-03-0111113114010.14412/2074-2711-2019-1-131-140832Antidepressant therapy in patients with cardiovascular diseasesV. E. Medvedev0E. A. Korovyakova1V. I. Frolova2E. V. Gushanskaya3Medical Institute, Peoples' Friendship University of RussiaMedical Institute, Peoples' Friendship University of RussiaMedical Institute, Peoples' Friendship University of RussiaMedical Institute, Peoples' Friendship University of RussiaDepression is the most common form of mental illness in patients with cardiovascular diseases (CVD). Depression and CVD can worsen the clinical and dynamic characteristics of each other. The timely detection and adequate psychopharmacotherapy of depressive states in patients with CVD are of great clinical, therapeutic, and prognostic importance. Anti-antidepressant therapy promotes a more pronounced somatic stabilizing effect in patients with CVD. Adverse events to the use of antidepressants in patients with CVD may be associated with their negative effect on the hepatic cytochrome CYP450 isoenzymes involved in the metabolism of various drugs. The authors' own data of clinical psychopharmacotherapeutic studies and the results of meta-analyses indicate the high efficiency and good tolerability of agomelatine, an antidepressant with an innovative mechanism of action, in a wide range of patientshttps://nnp.ima-press.net/nnp/article/view/1058cardiovascular diseasedepressiondepressionagomelatine |
spellingShingle | V. E. Medvedev E. A. Korovyakova V. I. Frolova E. V. Gushanskaya Antidepressant therapy in patients with cardiovascular diseases Неврология, нейропсихиатрия, психосоматика cardiovascular disease depression depression agomelatine |
title | Antidepressant therapy in patients with cardiovascular diseases |
title_full | Antidepressant therapy in patients with cardiovascular diseases |
title_fullStr | Antidepressant therapy in patients with cardiovascular diseases |
title_full_unstemmed | Antidepressant therapy in patients with cardiovascular diseases |
title_short | Antidepressant therapy in patients with cardiovascular diseases |
title_sort | antidepressant therapy in patients with cardiovascular diseases |
topic | cardiovascular disease depression depression agomelatine |
url | https://nnp.ima-press.net/nnp/article/view/1058 |
work_keys_str_mv | AT vemedvedev antidepressanttherapyinpatientswithcardiovasculardiseases AT eakorovyakova antidepressanttherapyinpatientswithcardiovasculardiseases AT vifrolova antidepressanttherapyinpatientswithcardiovasculardiseases AT evgushanskaya antidepressanttherapyinpatientswithcardiovasculardiseases |