Fast-tracking regenerative medicine for traumatic brain injury
Traumatic brain injury remains a global health crisis that spans all demographics, yet there exist limited treatment options that may effectively curtail its lingering symptoms. Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=7;spage=1179;epage=1190;aulast=Bonsack |
| _version_ | 1818891700497547264 |
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| author | Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V Borlongan |
| author_facet | Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V Borlongan |
| author_sort | Brooke Bonsack |
| collection | DOAJ |
| description | Traumatic brain injury remains a global health crisis that spans all demographics, yet there exist limited treatment options that may effectively curtail its lingering symptoms. Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death. Sequestering this inflammation as a means of ameliorating the greater symptomology of traumatic brain injury has emerged as an attractive treatment prospect. In this review, we recapitulate and evaluate the important developments relating to regulating traumatic brain injury-induced neuroinflammation, edema, and blood-brain barrier disintegration through pharmacotherapy and stem cell transplants. Although these studies of stand-alone treatments have yielded some positive results, more therapeutic outcomes have been documented from the promising area of combined drug and stem cell therapy. Harnessing the facilitatory properties of certain pharmaceuticals with the anti-inflammatory and regenerative effects of stem cell transplants creates a synergistic effect greater than the sum of its parts. The burgeoning evidence in favor of combined drug and stem cell therapies warrants more elaborate preclinical studies on this topic in order to pave the way for later clinical trials. |
| first_indexed | 2024-12-19T17:44:59Z |
| format | Article |
| id | doaj.art-3b0781378e884a1d83cade6c00ccfe2c |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-19T17:44:59Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-3b0781378e884a1d83cade6c00ccfe2c2022-12-21T20:12:06ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742020-01-011571179119010.4103/1673-5374.270294Fast-tracking regenerative medicine for traumatic brain injuryBrooke BonsackMatt HeyckChase KingsburyBlaise CozeneNadia SadanandanJea-Young LeeCesar V BorlonganTraumatic brain injury remains a global health crisis that spans all demographics, yet there exist limited treatment options that may effectively curtail its lingering symptoms. Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death. Sequestering this inflammation as a means of ameliorating the greater symptomology of traumatic brain injury has emerged as an attractive treatment prospect. In this review, we recapitulate and evaluate the important developments relating to regulating traumatic brain injury-induced neuroinflammation, edema, and blood-brain barrier disintegration through pharmacotherapy and stem cell transplants. Although these studies of stand-alone treatments have yielded some positive results, more therapeutic outcomes have been documented from the promising area of combined drug and stem cell therapy. Harnessing the facilitatory properties of certain pharmaceuticals with the anti-inflammatory and regenerative effects of stem cell transplants creates a synergistic effect greater than the sum of its parts. The burgeoning evidence in favor of combined drug and stem cell therapies warrants more elaborate preclinical studies on this topic in order to pave the way for later clinical trials.http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=7;spage=1179;epage=1190;aulast=Bonsackclinical trials; combined therapy; inflammatory cascade; neuroinflammation; neuroprotection; neurotrauma; pharmacotherapy; preclinical studies; secondary cell death; stem cells |
| spellingShingle | Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V Borlongan Fast-tracking regenerative medicine for traumatic brain injury Neural Regeneration Research clinical trials; combined therapy; inflammatory cascade; neuroinflammation; neuroprotection; neurotrauma; pharmacotherapy; preclinical studies; secondary cell death; stem cells |
| title | Fast-tracking regenerative medicine for traumatic brain injury |
| title_full | Fast-tracking regenerative medicine for traumatic brain injury |
| title_fullStr | Fast-tracking regenerative medicine for traumatic brain injury |
| title_full_unstemmed | Fast-tracking regenerative medicine for traumatic brain injury |
| title_short | Fast-tracking regenerative medicine for traumatic brain injury |
| title_sort | fast tracking regenerative medicine for traumatic brain injury |
| topic | clinical trials; combined therapy; inflammatory cascade; neuroinflammation; neuroprotection; neurotrauma; pharmacotherapy; preclinical studies; secondary cell death; stem cells |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=7;spage=1179;epage=1190;aulast=Bonsack |
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