Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells

Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells

Abstract Ovarian cancer is a leading cause of death among gynecologic tumors, often detected at advanced stages. Metabolic reprogramming and increased lipid biosynthesis are key factors driving cancer cell growth. Stearoyl-CoA desaturase 1 (SCD1) is a crucial enzyme involved in de novo lipid synthes...

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Bibliographic Details
Main Authors: Juwon Lee, Suin Jang, Jihye Im, Youngjin Han, Soochi Kim, HyunA Jo, Wenyu Wang, Untack Cho, Se Ik Kim, Aeran Seol, Boyun Kim, Yong Sang Song
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
Lipid metabolism
SCD1
ER stress
Apoptosis
Online Access:https://doi.org/10.1186/s13048-024-01389-1

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