Identification of Francisella novicida mutants that fail to induce prostaglandin E2 synthesis by infected macrophages.

Identification of Francisella novicida mutants that fail to induce prostaglandin E2 synthesis by infected macrophages.

Francisella tularensis is the causative agent of tularemia. We have previously shown that infection with F. tularensis Live Vaccine Strain (LVS) induces macrophages to synthesize prostaglandin E2 (PGE2). Synthesis of PGE2 by F. tularensis infected macrophages results in decreased T cell proliferat...

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Bibliographic Details
Main Authors: Matthew Dale Woolard, Lydia M Barrigan, James R Fuller, Adam S Buntzman, Joshua eBryan, Colin eManoil, Tom eKawula, Jeffrey A Frelinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Microbiology
Subjects:
Francisella tularensis
Macrophages
Prostaglandins
Francisella Pathogenicity Island (FPI)
intracellular growth
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00016/full

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