Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control
Resveratrol (RSV) has various pharmacological effects; however, few studies have directly addressed the possible antifatigue effects of long-term endurance exercise. The clinical use of RSV is limited by its poor water solubility and extremely short plasma half-life. Solid lipid nanoparticles (SLNs)...
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MDPI AG
2019-10-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/9/11/559 |
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| author | Jingyu Sun Yunhe Zhou Yajuan Su Sheng Li Jingmei Dong Qing He Yang Cao Tianfeng Lu Lili Qin |
| author_facet | Jingyu Sun Yunhe Zhou Yajuan Su Sheng Li Jingmei Dong Qing He Yang Cao Tianfeng Lu Lili Qin |
| author_sort | Jingyu Sun |
| collection | DOAJ |
| description | Resveratrol (RSV) has various pharmacological effects; however, few studies have directly addressed the possible antifatigue effects of long-term endurance exercise. The clinical use of RSV is limited by its poor water solubility and extremely short plasma half-life. Solid lipid nanoparticles (SLNs) are considered as reasonable drug delivery systems to overcome some of these drawbacks and expand its applications. In this study, RSV-SLNs were successfully prepared through emulsification and low-temperature solidification. Results showed that RSV-SLN supplementation effectively enhanced endurance performance. RSV-SLN supplementation might enhance mitochondrial function by ameliorating mitochondrial quality control (QC), which was superior to RSV application. These results revealed an unexpected role of RSV-SLN compared with RSV in terms of linking nutrient deprivation to mitochondrial oxidant production through mitochondrial QC. A mitochondrion-mediated pathway was likely involved in RSV-SLN, thereby improving endurance performance. Overall, this study highlighted new possibilities for anti-physical-fatigue strategies. |
| first_indexed | 2024-04-11T20:46:58Z |
| format | Article |
| id | doaj.art-3b0cbe8605254586bda83222e12d7f31 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-04-11T20:46:58Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-3b0cbe8605254586bda83222e12d7f312022-12-22T04:03:59ZengMDPI AGCrystals2073-43522019-10-0191155910.3390/cryst9110559cryst9110559Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality ControlJingyu Sun0Yunhe Zhou1Yajuan Su2Sheng Li3Jingmei Dong4Qing He5Yang Cao6Tianfeng Lu7Lili Qin8Sports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaSchool of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaSchool of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaSchool of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaResveratrol (RSV) has various pharmacological effects; however, few studies have directly addressed the possible antifatigue effects of long-term endurance exercise. The clinical use of RSV is limited by its poor water solubility and extremely short plasma half-life. Solid lipid nanoparticles (SLNs) are considered as reasonable drug delivery systems to overcome some of these drawbacks and expand its applications. In this study, RSV-SLNs were successfully prepared through emulsification and low-temperature solidification. Results showed that RSV-SLN supplementation effectively enhanced endurance performance. RSV-SLN supplementation might enhance mitochondrial function by ameliorating mitochondrial quality control (QC), which was superior to RSV application. These results revealed an unexpected role of RSV-SLN compared with RSV in terms of linking nutrient deprivation to mitochondrial oxidant production through mitochondrial QC. A mitochondrion-mediated pathway was likely involved in RSV-SLN, thereby improving endurance performance. Overall, this study highlighted new possibilities for anti-physical-fatigue strategies.https://www.mdpi.com/2073-4352/9/11/559resveratrolsolid lipid nanoparticlesendurance exercisemitochondrial nutrientsmitochondrial quality control |
| spellingShingle | Jingyu Sun Yunhe Zhou Yajuan Su Sheng Li Jingmei Dong Qing He Yang Cao Tianfeng Lu Lili Qin Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control Crystals resveratrol solid lipid nanoparticles endurance exercise mitochondrial nutrients mitochondrial quality control |
| title | Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control |
| title_full | Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control |
| title_fullStr | Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control |
| title_full_unstemmed | Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control |
| title_short | Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control |
| title_sort | resveratrol loaded solid lipid nanoparticle supplementation ameliorates physical fatigue by improving mitochondrial quality control |
| topic | resveratrol solid lipid nanoparticles endurance exercise mitochondrial nutrients mitochondrial quality control |
| url | https://www.mdpi.com/2073-4352/9/11/559 |
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