Melatonin and the Prevention and Management of Delirium: A Scoping Study
BackgroundThe therapeutic benefit of melatonin in the prevention and treatment of delirium is uncertain.ObjectiveTo perform a scoping study to describe the existing literature regarding the use of melatonin and ramelteon in the prevention and treatment of delirium.MethodsWe performed a scoping study...
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| Format: | Article |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmed.2017.00242/full |
| _version_ | 1818602911536513024 |
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| author | Sin Wei Choy Sin Wei Choy Aun Chian Yeoh Aun Chian Yeoh Zhao Zheng Lee Zhao Zheng Lee Velandai Srikanth Velandai Srikanth Chris Moran Chris Moran Chris Moran |
| author_facet | Sin Wei Choy Sin Wei Choy Aun Chian Yeoh Aun Chian Yeoh Zhao Zheng Lee Zhao Zheng Lee Velandai Srikanth Velandai Srikanth Chris Moran Chris Moran Chris Moran |
| author_sort | Sin Wei Choy |
| collection | DOAJ |
| description | BackgroundThe therapeutic benefit of melatonin in the prevention and treatment of delirium is uncertain.ObjectiveTo perform a scoping study to describe the existing literature regarding the use of melatonin and ramelteon in the prevention and treatment of delirium.MethodsWe performed a scoping study using the Arksey and O’Malley framework to explore our objective. Two independent panels searched MEDLINE, OVID, EMBASE, PubMed, Google Scholar, and Cochrane Library for relevant articles up to November 2017 describing the use of melatonin and ramelteon in the prevention or management of delirium. We extracted relevant summary data from the studies and attempted to draw conclusion regarding benefit.ResultsWe summarized evidence from 20 relevant articles. There were a total of nine articles: five randomized controlled trials (RCTs), two retrospective medical record reviews, one non-randomized observational study, and one case report describing the role of either melatonin or ramelteon in preventing delirium. There were a total of 11 studies studying the role of either melatonin or ramelteon in the management of established delirium. None of these were RCT and were predominantly case series and case reports. Four of the five trials studying the effect of melatonin analogs in preventing delirium reported a beneficial effect but study heterogeneity limited any broad recommendations. Similarly, the lack of any well-designed trials limits any recommendations regarding the effect of melatonin analogs in treating delirium.ConclusionLarge, well-designed clinical trials are required to explore the potential beneficial effects of melatonin and ramelteon on delirium prevention and management. |
| first_indexed | 2024-12-16T13:14:48Z |
| format | Article |
| id | doaj.art-3b0d5eeda7cd4ae08781368d4be898fe |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-16T13:14:48Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3b0d5eeda7cd4ae08781368d4be898fe2022-12-21T22:30:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-01-01410.3389/fmed.2017.00242305937Melatonin and the Prevention and Management of Delirium: A Scoping StudySin Wei Choy0Sin Wei Choy1Aun Chian Yeoh2Aun Chian Yeoh3Zhao Zheng Lee4Zhao Zheng Lee5Velandai Srikanth6Velandai Srikanth7Chris Moran8Chris Moran9Chris Moran10Department of Aged Care, Alfred Health, Melbourne, VIC, AustraliaDepartment of Geriatric Medicine, Princess Alexandra Hospital, Woolloongabba, QLD, AustraliaDepartment of Medicine, Peninsula Health, Frankston, VIC, AustraliaPeninsula Clinical School, Central Clinical School, Monash University, Frankston, VIC, AustraliaDepartment of Medicine, Peninsula Health, Frankston, VIC, AustraliaPeninsula Clinical School, Central Clinical School, Monash University, Frankston, VIC, AustraliaDepartment of Medicine, Peninsula Health, Frankston, VIC, AustraliaPeninsula Clinical School, Central Clinical School, Monash University, Frankston, VIC, AustraliaDepartment of Aged Care, Alfred Health, Melbourne, VIC, AustraliaDepartment of Medicine, Peninsula Health, Frankston, VIC, AustraliaPeninsula Clinical School, Central Clinical School, Monash University, Frankston, VIC, AustraliaBackgroundThe therapeutic benefit of melatonin in the prevention and treatment of delirium is uncertain.ObjectiveTo perform a scoping study to describe the existing literature regarding the use of melatonin and ramelteon in the prevention and treatment of delirium.MethodsWe performed a scoping study using the Arksey and O’Malley framework to explore our objective. Two independent panels searched MEDLINE, OVID, EMBASE, PubMed, Google Scholar, and Cochrane Library for relevant articles up to November 2017 describing the use of melatonin and ramelteon in the prevention or management of delirium. We extracted relevant summary data from the studies and attempted to draw conclusion regarding benefit.ResultsWe summarized evidence from 20 relevant articles. There were a total of nine articles: five randomized controlled trials (RCTs), two retrospective medical record reviews, one non-randomized observational study, and one case report describing the role of either melatonin or ramelteon in preventing delirium. There were a total of 11 studies studying the role of either melatonin or ramelteon in the management of established delirium. None of these were RCT and were predominantly case series and case reports. Four of the five trials studying the effect of melatonin analogs in preventing delirium reported a beneficial effect but study heterogeneity limited any broad recommendations. Similarly, the lack of any well-designed trials limits any recommendations regarding the effect of melatonin analogs in treating delirium.ConclusionLarge, well-designed clinical trials are required to explore the potential beneficial effects of melatonin and ramelteon on delirium prevention and management.http://journal.frontiersin.org/article/10.3389/fmed.2017.00242/fulldeliriummelatoninmelatonin agonistramelteonpreventionmanagement |
| spellingShingle | Sin Wei Choy Sin Wei Choy Aun Chian Yeoh Aun Chian Yeoh Zhao Zheng Lee Zhao Zheng Lee Velandai Srikanth Velandai Srikanth Chris Moran Chris Moran Chris Moran Melatonin and the Prevention and Management of Delirium: A Scoping Study Frontiers in Medicine delirium melatonin melatonin agonist ramelteon prevention management |
| title | Melatonin and the Prevention and Management of Delirium: A Scoping Study |
| title_full | Melatonin and the Prevention and Management of Delirium: A Scoping Study |
| title_fullStr | Melatonin and the Prevention and Management of Delirium: A Scoping Study |
| title_full_unstemmed | Melatonin and the Prevention and Management of Delirium: A Scoping Study |
| title_short | Melatonin and the Prevention and Management of Delirium: A Scoping Study |
| title_sort | melatonin and the prevention and management of delirium a scoping study |
| topic | delirium melatonin melatonin agonist ramelteon prevention management |
| url | http://journal.frontiersin.org/article/10.3389/fmed.2017.00242/full |
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