Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee Arthroplasty
Inflammatory arthritis affects the level of synovial inflammatory factors, which makes it more difficult to diagnose prosthetic joint infection (PJI) patients with inflammatory arthritis. The aim of this study was to analyze synovial interleukin levels to distinguish between PJI and active rheumatoi...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/5/1196 |
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| author | Leilei Qin Chengcheng Du Jianye Yang Hai Wang Xudong Su Li Wei Chen Zhao Cheng Chen Hong Chen Ning Hu Wei Huang |
| author_facet | Leilei Qin Chengcheng Du Jianye Yang Hai Wang Xudong Su Li Wei Chen Zhao Cheng Chen Hong Chen Ning Hu Wei Huang |
| author_sort | Leilei Qin |
| collection | DOAJ |
| description | Inflammatory arthritis affects the level of synovial inflammatory factors, which makes it more difficult to diagnose prosthetic joint infection (PJI) patients with inflammatory arthritis. The aim of this study was to analyze synovial interleukin levels to distinguish between PJI and active rheumatoid arthritis (RA) after a hip or knee arthroplasty. From September 2019 to September 2021, we prospectively enrolled patients with joint pain after arthroplasty due to aseptic prosthesis loosening (n = 39), acute RA (n = 26), and PJI (n = 37). Synovial fluid from the affected joint is obtained and tested with a standard enzyme-linked immunosorbent assay. Receiver operating characteristic curve (ROC) was analyzed for each biomarker. Interleukin (IL)-1β, IL-6, and IL-8 showed promising value in differentiating of aseptic loosening from PJI, with areas under the curves (AUCs) of 0.9590, 0.9506, and 0.9616, respectively. Synovial IL-1β, IL-6, and IL-8 showed limited value in distinguishing between PJI and acute episodes of RA after arthroplasty, with AUCs of 0.7507, 0.7069, and 0.7034, respectively. Interleukins showed satisfactory efficacy in differentiating aseptic loosening from PJI. However, when pain after arthroplasty results from an acute episode of RA, current synovial interleukin levels do not accurately rule out the presence of PJI. |
| first_indexed | 2024-03-10T03:02:44Z |
| format | Article |
| id | doaj.art-3b0deeb3964f4357873b901bd3f5b9fd |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T03:02:44Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-3b0deeb3964f4357873b901bd3f5b9fd2023-11-23T10:40:44ZengMDPI AGDiagnostics2075-44182022-05-01125119610.3390/diagnostics12051196Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee ArthroplastyLeilei Qin0Chengcheng Du1Jianye Yang2Hai Wang3Xudong Su4Li Wei5Chen Zhao6Cheng Chen7Hong Chen8Ning Hu9Wei Huang10Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaInflammatory arthritis affects the level of synovial inflammatory factors, which makes it more difficult to diagnose prosthetic joint infection (PJI) patients with inflammatory arthritis. The aim of this study was to analyze synovial interleukin levels to distinguish between PJI and active rheumatoid arthritis (RA) after a hip or knee arthroplasty. From September 2019 to September 2021, we prospectively enrolled patients with joint pain after arthroplasty due to aseptic prosthesis loosening (n = 39), acute RA (n = 26), and PJI (n = 37). Synovial fluid from the affected joint is obtained and tested with a standard enzyme-linked immunosorbent assay. Receiver operating characteristic curve (ROC) was analyzed for each biomarker. Interleukin (IL)-1β, IL-6, and IL-8 showed promising value in differentiating of aseptic loosening from PJI, with areas under the curves (AUCs) of 0.9590, 0.9506, and 0.9616, respectively. Synovial IL-1β, IL-6, and IL-8 showed limited value in distinguishing between PJI and acute episodes of RA after arthroplasty, with AUCs of 0.7507, 0.7069, and 0.7034, respectively. Interleukins showed satisfactory efficacy in differentiating aseptic loosening from PJI. However, when pain after arthroplasty results from an acute episode of RA, current synovial interleukin levels do not accurately rule out the presence of PJI.https://www.mdpi.com/2075-4418/12/5/1196prosthetic joint infectionsynovial fluidinflammatory markerinterleukinsrheumatoid arthritis |
| spellingShingle | Leilei Qin Chengcheng Du Jianye Yang Hai Wang Xudong Su Li Wei Chen Zhao Cheng Chen Hong Chen Ning Hu Wei Huang Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee Arthroplasty Diagnostics prosthetic joint infection synovial fluid inflammatory marker interleukins rheumatoid arthritis |
| title | Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee Arthroplasty |
| title_full | Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee Arthroplasty |
| title_fullStr | Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee Arthroplasty |
| title_full_unstemmed | Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee Arthroplasty |
| title_short | Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee Arthroplasty |
| title_sort | synovial fluid interleukin levels cannot distinguish between prosthetic joint infection and active rheumatoid arthritis after hip or knee arthroplasty |
| topic | prosthetic joint infection synovial fluid inflammatory marker interleukins rheumatoid arthritis |
| url | https://www.mdpi.com/2075-4418/12/5/1196 |
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