Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes
New azo ligand, 2[(Aminoantipyren) azo]-4, 5-bis(4-Methoxyphenyl)-H imidazole, (AAMPI) was prepared through coupling reaction of 4-amino antipyrine with 4, 5-bis (4-methoxyphenyl) imidazole. Then, complexation of ligand with ions Co(Ⅱ), Ni(Ⅱ), Cu(Ⅱ), Zn(Ⅱ), Cd(Ⅱ) and Hg(Ⅱ) were prepared to yield six...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2018-03-01
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| Series: | Nano Biomedicine and Engineering |
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| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v10i1.p46-55 |
| _version_ | 1797673365424570368 |
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| author | Siham Sami Al-Muhanaa Abbas Hmood Al-Khafagy |
| author_facet | Siham Sami Al-Muhanaa Abbas Hmood Al-Khafagy |
| author_sort | Siham Sami Al-Muhanaa |
| collection | DOAJ |
| description | New azo ligand, 2[(Aminoantipyren) azo]-4, 5-bis(4-Methoxyphenyl)-H imidazole, (AAMPI) was prepared through coupling reaction of 4-amino antipyrine with 4, 5-bis (4-methoxyphenyl) imidazole. Then, complexation of ligand with ions Co(Ⅱ), Ni(Ⅱ), Cu(Ⅱ), Zn(Ⅱ), Cd(Ⅱ) and Hg(Ⅱ) were prepared to yield six complexes. The optimal conditions were studied for all complexes in the mole ratio between metal: ligand (M: L) as of 1:2 in the general formula [M(L)2]Cl2·H2O. Present results found the azo ligand was tridentate. The structures of ligand with complexes were identified by ultraviolet-visible spectroscopy (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1HNMR), carbon-13 nuclear magnetic resonance (13CNMR), mass spectrometry, elemental analysis (CHN), magnetic susceptibility and molar conductance. All the complexes exhibit octahedral geometry around the metal center. The antibacterial activities of synthesized compound were tested against the gram-negative, gram-positive bacteria and fungus. The results showed that the metal complexes exhibited antibacterial and antifungal activities compared with free ligand. |
| first_indexed | 2024-03-11T21:43:27Z |
| format | Article |
| id | doaj.art-3b0ea1a81190494ab50473615caa6f50 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:43:27Z |
| publishDate | 2018-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-3b0ea1a81190494ab50473615caa6f502023-09-26T11:01:50ZengTsinghua University PressNano Biomedicine and Engineering2150-55782018-03-01101465510.5101/nbe.v10i1.p46-55Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate ComplexesSiham Sami Al-Muhanaa0Abbas Hmood Al-Khafagy1Department of Chemistry, Faculty of Education for Women, University of Kufa, 54001 Najaf, IraqDepartment of Chemistry, Faculty of Education for Women, University of Kufa, 54001 Najaf, IraqNew azo ligand, 2[(Aminoantipyren) azo]-4, 5-bis(4-Methoxyphenyl)-H imidazole, (AAMPI) was prepared through coupling reaction of 4-amino antipyrine with 4, 5-bis (4-methoxyphenyl) imidazole. Then, complexation of ligand with ions Co(Ⅱ), Ni(Ⅱ), Cu(Ⅱ), Zn(Ⅱ), Cd(Ⅱ) and Hg(Ⅱ) were prepared to yield six complexes. The optimal conditions were studied for all complexes in the mole ratio between metal: ligand (M: L) as of 1:2 in the general formula [M(L)2]Cl2·H2O. Present results found the azo ligand was tridentate. The structures of ligand with complexes were identified by ultraviolet-visible spectroscopy (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1HNMR), carbon-13 nuclear magnetic resonance (13CNMR), mass spectrometry, elemental analysis (CHN), magnetic susceptibility and molar conductance. All the complexes exhibit octahedral geometry around the metal center. The antibacterial activities of synthesized compound were tested against the gram-negative, gram-positive bacteria and fungus. The results showed that the metal complexes exhibited antibacterial and antifungal activities compared with free ligand.https://www.sciopen.com/article/10.5101/nbe.v10i1.p46-55azo ligandimidazolemetal complexescoupling reactionbiological activity |
| spellingShingle | Siham Sami Al-Muhanaa Abbas Hmood Al-Khafagy Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes Nano Biomedicine and Engineering azo ligand imidazole metal complexes coupling reaction biological activity |
| title | Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes |
| title_full | Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes |
| title_fullStr | Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes |
| title_full_unstemmed | Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes |
| title_short | Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes |
| title_sort | preparation and biological activities of new heterocyclic azo ligand and some of its chelate complexes |
| topic | azo ligand imidazole metal complexes coupling reaction biological activity |
| url | https://www.sciopen.com/article/10.5101/nbe.v10i1.p46-55 |
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