Compedium model using frequency / cumulative distribution function for receptors of survival proteins: Epidermal growth factor and insulin
In this paper I used the frequency and cumulative distribution functions to make a best model of the receptors of the survival proteins i.e. Epidermal Growth Factor Receptor (EGFR) and Insulin Receptor (IRS) using ten concentrations combination of TNF, EGF and Insulin. It has been revealed that surv...
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| Format: | Article |
| Language: | English |
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International Academy of Ecology and Environmental Sciences
2016-12-01
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| Series: | Network Biology |
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| Online Access: | http://www.iaees.org/publications/journals/nb/articles/2016-6(4)/compedium-model-using-frequency-cumulative-distribution-function.pdf |
| _version_ | 1818447865812353024 |
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| author | Shruti Jain |
| author_facet | Shruti Jain |
| author_sort | Shruti Jain |
| collection | DOAJ |
| description | In this paper I used the frequency and cumulative distribution functions to make a best model of the receptors of the survival proteins i.e. Epidermal Growth Factor Receptor (EGFR) and Insulin Receptor (IRS) using ten concentrations combination of TNF, EGF and Insulin. It has been revealed that survival and apoptosis signals induced by the receptors of EGF and insulin are temporarily separated and this is reflected in my model by the differences between the values of the parameters used. I conducted the analysis using KS-d, KS, AD stat, AD p-value, chi square, chi square p-value and chi square df for different distribution functions for EGFR and IRS. The frequency and cumulative distribution curves for different distribution techniques like exponential, log-normal, normal, gamma, chi-square etc are plotted using chi- square tests. |
| first_indexed | 2024-12-14T20:10:25Z |
| format | Article |
| id | doaj.art-3b12dc98269a482d83b511ac7d5d01e3 |
| institution | Directory Open Access Journal |
| issn | 2220-8879 2220-8879 |
| language | English |
| last_indexed | 2024-12-14T20:10:25Z |
| publishDate | 2016-12-01 |
| publisher | International Academy of Ecology and Environmental Sciences |
| record_format | Article |
| series | Network Biology |
| spelling | doaj.art-3b12dc98269a482d83b511ac7d5d01e32022-12-21T22:48:55ZengInternational Academy of Ecology and Environmental SciencesNetwork Biology2220-88792220-88792016-12-0164101110Compedium model using frequency / cumulative distribution function for receptors of survival proteins: Epidermal growth factor and insulinShruti Jain0Department of Electronics and Communication Engineering, Jaypee University of Information Technology, Solan-173234, IndiaIn this paper I used the frequency and cumulative distribution functions to make a best model of the receptors of the survival proteins i.e. Epidermal Growth Factor Receptor (EGFR) and Insulin Receptor (IRS) using ten concentrations combination of TNF, EGF and Insulin. It has been revealed that survival and apoptosis signals induced by the receptors of EGF and insulin are temporarily separated and this is reflected in my model by the differences between the values of the parameters used. I conducted the analysis using KS-d, KS, AD stat, AD p-value, chi square, chi square p-value and chi square df for different distribution functions for EGFR and IRS. The frequency and cumulative distribution curves for different distribution techniques like exponential, log-normal, normal, gamma, chi-square etc are plotted using chi- square tests.http://www.iaees.org/publications/journals/nb/articles/2016-6(4)/compedium-model-using-frequency-cumulative-distribution-function.pdfEGFinsulinreceptorsfrequency distributioncumulative distribution |
| spellingShingle | Shruti Jain Compedium model using frequency / cumulative distribution function for receptors of survival proteins: Epidermal growth factor and insulin Network Biology EGF insulin receptors frequency distribution cumulative distribution |
| title | Compedium model using frequency / cumulative distribution function for receptors of survival proteins: Epidermal growth factor and insulin |
| title_full | Compedium model using frequency / cumulative distribution function for receptors of survival proteins: Epidermal growth factor and insulin |
| title_fullStr | Compedium model using frequency / cumulative distribution function for receptors of survival proteins: Epidermal growth factor and insulin |
| title_full_unstemmed | Compedium model using frequency / cumulative distribution function for receptors of survival proteins: Epidermal growth factor and insulin |
| title_short | Compedium model using frequency / cumulative distribution function for receptors of survival proteins: Epidermal growth factor and insulin |
| title_sort | compedium model using frequency cumulative distribution function for receptors of survival proteins epidermal growth factor and insulin |
| topic | EGF insulin receptors frequency distribution cumulative distribution |
| url | http://www.iaees.org/publications/journals/nb/articles/2016-6(4)/compedium-model-using-frequency-cumulative-distribution-function.pdf |
| work_keys_str_mv | AT shrutijain compediummodelusingfrequencycumulativedistributionfunctionforreceptorsofsurvivalproteinsepidermalgrowthfactorandinsulin |