Large-Scale Comparison of Toxin and Antitoxins in <i>Listeria monocytogenes</i>
Toxin−antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in <i>Listeria monocytogenes</i> (<i>Lm</i&...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/12/1/29 |
| _version_ | 1811303614659952640 |
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| author | José Antonio Agüero Hatice Akarsu Lisandra Aguilar-Bultet Anna Oevermann Laurent Falquet |
| author_facet | José Antonio Agüero Hatice Akarsu Lisandra Aguilar-Bultet Anna Oevermann Laurent Falquet |
| author_sort | José Antonio Agüero |
| collection | DOAJ |
| description | Toxin−antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in <i>Listeria monocytogenes</i> (<i>Lm</i>), a pathogenic bacterium of the Firmicutes phylum causing infections in animals and humans. Using our recently published TASmania database, we focused on the known and new putative TASs in 352 <i>Listeria monocytogenes</i> genomes and identified the putative core gene TASs (cgTASs) with the Pasteur BIGSdb-Lm database and, by complementarity, the putative accessory gene TAS (acTASs). We combined the cgTASs with those of an additional 227 <i>L. monocytogenes</i> isolates from our previous studies containing metadata information. We discovered that the differences in 14 cgTAS alleles are sufficient to separate the four main lineages of <i>Listeria monocytogenes</i>. Analyzing these differences in more details, we uncovered potentially co-evolving residues in some pairs of proteins in cgTASs, probably essential for protein−protein interactions within the TAS complex. |
| first_indexed | 2024-04-13T07:51:36Z |
| format | Article |
| id | doaj.art-3b1445e70ff946f5989595d77c511845 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-13T07:51:36Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-3b1445e70ff946f5989595d77c5118452022-12-22T02:55:31ZengMDPI AGToxins2072-66512020-01-011212910.3390/toxins12010029toxins12010029Large-Scale Comparison of Toxin and Antitoxins in <i>Listeria monocytogenes</i>José Antonio Agüero0Hatice Akarsu1Lisandra Aguilar-Bultet2Anna Oevermann3Laurent Falquet4CENSA National Center for Animal and Plant Health, San José de las Lajas Municipality 32700, Mayabeque, CubaSIB Swiss Institute of Bioinformatics, 1015 Lausanne, SwitzerlandVetsuisse Faculty, University of Bern, 3012 Bern, SwitzerlandVetsuisse Faculty, University of Bern, 3012 Bern, SwitzerlandSIB Swiss Institute of Bioinformatics, 1015 Lausanne, SwitzerlandToxin−antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in <i>Listeria monocytogenes</i> (<i>Lm</i>), a pathogenic bacterium of the Firmicutes phylum causing infections in animals and humans. Using our recently published TASmania database, we focused on the known and new putative TASs in 352 <i>Listeria monocytogenes</i> genomes and identified the putative core gene TASs (cgTASs) with the Pasteur BIGSdb-Lm database and, by complementarity, the putative accessory gene TAS (acTASs). We combined the cgTASs with those of an additional 227 <i>L. monocytogenes</i> isolates from our previous studies containing metadata information. We discovered that the differences in 14 cgTAS alleles are sufficient to separate the four main lineages of <i>Listeria monocytogenes</i>. Analyzing these differences in more details, we uncovered potentially co-evolving residues in some pairs of proteins in cgTASs, probably essential for protein−protein interactions within the TAS complex.https://www.mdpi.com/2072-6651/12/1/29toxin–antitoxin systems<i>listeria monocytogenes</i>co-evolution |
| spellingShingle | José Antonio Agüero Hatice Akarsu Lisandra Aguilar-Bultet Anna Oevermann Laurent Falquet Large-Scale Comparison of Toxin and Antitoxins in <i>Listeria monocytogenes</i> Toxins toxin–antitoxin systems <i>listeria monocytogenes</i> co-evolution |
| title | Large-Scale Comparison of Toxin and Antitoxins in <i>Listeria monocytogenes</i> |
| title_full | Large-Scale Comparison of Toxin and Antitoxins in <i>Listeria monocytogenes</i> |
| title_fullStr | Large-Scale Comparison of Toxin and Antitoxins in <i>Listeria monocytogenes</i> |
| title_full_unstemmed | Large-Scale Comparison of Toxin and Antitoxins in <i>Listeria monocytogenes</i> |
| title_short | Large-Scale Comparison of Toxin and Antitoxins in <i>Listeria monocytogenes</i> |
| title_sort | large scale comparison of toxin and antitoxins in i listeria monocytogenes i |
| topic | toxin–antitoxin systems <i>listeria monocytogenes</i> co-evolution |
| url | https://www.mdpi.com/2072-6651/12/1/29 |
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