The value of IgG to IgM ratio in predicting secondary dengue infection
Background The determination of primary or secondary dengue infection using hemagglutination inhibition (HI) test is time-con- suming. The IgG to IgM ratio which can be obtained earlier was used by several studies to differentiate secondary from primary infection, but they still reported various cut...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2016-10-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/911 |
| _version_ | 1818512232169865216 |
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| author | I Putu Gede Karyana Hendra Santoso Bagus Ngurah Putu Arhana |
| author_facet | I Putu Gede Karyana Hendra Santoso Bagus Ngurah Putu Arhana |
| author_sort | I Putu Gede Karyana |
| collection | DOAJ |
| description | Background The determination of primary or secondary dengue
infection using hemagglutination inhibition (HI) test is time-con-
suming. The IgG to IgM ratio which can be obtained earlier was
used by several studies to differentiate secondary from primary
infection, but they still reported various cut-off points.
Objective To find the diagnostic value and best cut off point of
IgG to IgM ratio for predicting secondary dengue infection.
Methods This was a prospective study carried out between July
2003 and June 2004. Children with suspected dengue hemor-
rhagic fever (DHF) were tested for HI during acute and convales-
cent phase. The IgG and IgM titer were examined during the acute
phase using ELISA method.
Results Sixty-two children were recruited, 48 with secondary in-
fection and 14 with primary infection. The prevalence of second-
ary infection was 77%. The best cut off point of the IgG to IgM ratio
to predict secondary infection was >1.1 with sensitivity of 87.5%,
specificity 92.9%, likelihood ratio 12.3, and post test probability
97.7%.
Conclusion The IgG to IgM ratio of >1.1 is a good predictor for
secondary infection |
| first_indexed | 2024-12-10T23:43:59Z |
| format | Article |
| id | doaj.art-3b167b326cee4f10be1d5559f708fdb9 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-10T23:43:59Z |
| publishDate | 2016-10-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-3b167b326cee4f10be1d5559f708fdb92022-12-22T01:28:58ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-10-01463113710.14238/pi46.3.2006.113-7769The value of IgG to IgM ratio in predicting secondary dengue infectionI Putu Gede KaryanaHendra SantosoBagus Ngurah Putu ArhanaBackground The determination of primary or secondary dengue infection using hemagglutination inhibition (HI) test is time-con- suming. The IgG to IgM ratio which can be obtained earlier was used by several studies to differentiate secondary from primary infection, but they still reported various cut-off points. Objective To find the diagnostic value and best cut off point of IgG to IgM ratio for predicting secondary dengue infection. Methods This was a prospective study carried out between July 2003 and June 2004. Children with suspected dengue hemor- rhagic fever (DHF) were tested for HI during acute and convales- cent phase. The IgG and IgM titer were examined during the acute phase using ELISA method. Results Sixty-two children were recruited, 48 with secondary in- fection and 14 with primary infection. The prevalence of second- ary infection was 77%. The best cut off point of the IgG to IgM ratio to predict secondary infection was >1.1 with sensitivity of 87.5%, specificity 92.9%, likelihood ratio 12.3, and post test probability 97.7%. Conclusion The IgG to IgM ratio of >1.1 is a good predictor for secondary infectionhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/911dengue hemorrhagic fever (DHF)primary and secondary infectionhemagglutination inhibition (HI) testratio of IgG:IgM |
| spellingShingle | I Putu Gede Karyana Hendra Santoso Bagus Ngurah Putu Arhana The value of IgG to IgM ratio in predicting secondary dengue infection Paediatrica Indonesiana dengue hemorrhagic fever (DHF) primary and secondary infection hemagglutination inhibition (HI) test ratio of IgG:IgM |
| title | The value of IgG to IgM ratio in predicting secondary dengue infection |
| title_full | The value of IgG to IgM ratio in predicting secondary dengue infection |
| title_fullStr | The value of IgG to IgM ratio in predicting secondary dengue infection |
| title_full_unstemmed | The value of IgG to IgM ratio in predicting secondary dengue infection |
| title_short | The value of IgG to IgM ratio in predicting secondary dengue infection |
| title_sort | value of igg to igm ratio in predicting secondary dengue infection |
| topic | dengue hemorrhagic fever (DHF) primary and secondary infection hemagglutination inhibition (HI) test ratio of IgG:IgM |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/911 |
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