Synthesis, In Silico and In Vitro Assessment of New Quinazolinones as Anticancer Agents via Potential AKT Inhibition

Synthesis, In Silico and In Vitro Assessment of New Quinazolinones as Anticancer Agents via Potential AKT Inhibition

A series of novel quinazolinone derivatives (<b>2</b>–<b>13</b>) was synthesized and examined for their cytotoxicity to HepG2, MCF-7, and Caco-2 in an MTT assay. Among these derivatives, compounds <b>4</b> and <b>9</b> exhibited significant cytotoxic a...

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Bibliographic Details
Main Authors: Ahmed A. Noser, Mohamed El-Naggar, Thoria Donia, Aboubakr H. Abdelmonsef
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
AKT1
cancer
quinazolinone
docking study
cytotoxic activity
Online Access:https://www.mdpi.com/1420-3049/25/20/4780

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