Mitochondrial Energy Metabolism and Thyroid Cancers
Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Endocrine Society
2015-06-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-117.pdf |
| _version_ | 1818569707637178368 |
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| author | Junguee Lee Joon Young Chang Yea Eun Kang Shinae Yi Min Hee Lee Kyong Hye Joung Kun Soon Kim Minho Shong |
| author_facet | Junguee Lee Joon Young Chang Yea Eun Kang Shinae Yi Min Hee Lee Kyong Hye Joung Kun Soon Kim Minho Shong |
| author_sort | Junguee Lee |
| collection | DOAJ |
| description | Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhibition of oncogenic pathways did not provide a significant survival benefit in advanced progressive thyroid cancer that is resistant to radioactive iodine therapy. Accumulating evidence clearly shows that cellular energy metabolism, which is controlled by oncogenes and other tumor-related factors, is a critical factor determining the clinical phenotypes of cancer. However, the role and nature of energy metabolism in thyroid cancer remain unclear. In this article, we discuss the role of cellular energy metabolism, particularly mitochondrial energy metabolism, in thyroid cancer. Determining the molecular nature of metabolic remodeling in thyroid cancer may provide new biomarkers and therapeutic targets that may be useful in the management of refractory thyroid cancers. |
| first_indexed | 2024-12-14T06:51:19Z |
| format | Article |
| id | doaj.art-3b19dba7a051444db37042b56fbb8b2e |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-14T06:51:19Z |
| publishDate | 2015-06-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-3b19dba7a051444db37042b56fbb8b2e2022-12-21T23:12:53ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782015-06-0130211712310.3803/EnM.2015.30.2.11720794Mitochondrial Energy Metabolism and Thyroid CancersJunguee LeeJoon Young ChangYea Eun KangShinae YiMin Hee LeeKyong Hye JoungKun Soon KimMinho ShongPrimary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhibition of oncogenic pathways did not provide a significant survival benefit in advanced progressive thyroid cancer that is resistant to radioactive iodine therapy. Accumulating evidence clearly shows that cellular energy metabolism, which is controlled by oncogenes and other tumor-related factors, is a critical factor determining the clinical phenotypes of cancer. However, the role and nature of energy metabolism in thyroid cancer remain unclear. In this article, we discuss the role of cellular energy metabolism, particularly mitochondrial energy metabolism, in thyroid cancer. Determining the molecular nature of metabolic remodeling in thyroid cancer may provide new biomarkers and therapeutic targets that may be useful in the management of refractory thyroid cancers.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-117.pdfThyroid neoplasmsMitochondriaEnergy metabolism |
| spellingShingle | Junguee Lee Joon Young Chang Yea Eun Kang Shinae Yi Min Hee Lee Kyong Hye Joung Kun Soon Kim Minho Shong Mitochondrial Energy Metabolism and Thyroid Cancers Endocrinology and Metabolism Thyroid neoplasms Mitochondria Energy metabolism |
| title | Mitochondrial Energy Metabolism and Thyroid Cancers |
| title_full | Mitochondrial Energy Metabolism and Thyroid Cancers |
| title_fullStr | Mitochondrial Energy Metabolism and Thyroid Cancers |
| title_full_unstemmed | Mitochondrial Energy Metabolism and Thyroid Cancers |
| title_short | Mitochondrial Energy Metabolism and Thyroid Cancers |
| title_sort | mitochondrial energy metabolism and thyroid cancers |
| topic | Thyroid neoplasms Mitochondria Energy metabolism |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-117.pdf |
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