Small-Molecule Mn Antioxidants in Caenorhabditis elegans and Deinococcus radiodurans Supplant MnSOD Enzymes during Aging and Irradiation

Small-Molecule Mn Antioxidants in Caenorhabditis elegans and Deinococcus radiodurans Supplant MnSOD Enzymes during Aging and Irradiation

ABSTRACT Denham Harman’s oxidative damage theory identifies superoxide (O2•−) radicals as central agents of aging and radiation injury, with Mn2+-dependent superoxide dismutase (MnSOD) as the principal O2•−-scavenger. However, in the radiation-resistant nematode Caenorhabditis elegans, the mitochond...

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Bibliographic Details
Main Authors: Elena K. Gaidamakova, Ajay Sharma, Vera Y. Matrosova, Olga Grichenko, Robert P. Volpe, Rok Tkavc, Isabel H. Conze, Polina Klimenkova, Irina Balygina, William H. Horne, Cene Gostinčar, Xiao Chen, Kira S. Makarova, Igor Shuryak, Chandra Srinivasan, Belinda Jackson-Thompson, Brian M. Hoffman, Michael J. Daly
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
ionizing radiation
aging
desiccation
ROS
Mn antioxidants
MnSOD
Online Access:https://journals.asm.org/doi/10.1128/mbio.03394-21

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