Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background
The data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic coli...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340917300781 |
| _version_ | 1811287621069963264 |
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| author | Vishal Singh Beng San Yeoh Marit Nilsen-Hamilton Thorsten Berger Tak W. Mak Matam Vijay-Kumar |
| author_facet | Vishal Singh Beng San Yeoh Marit Nilsen-Hamilton Thorsten Berger Tak W. Mak Matam Vijay-Kumar |
| author_sort | Vishal Singh |
| collection | DOAJ |
| description | The data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice. |
| first_indexed | 2024-04-13T03:21:47Z |
| format | Article |
| id | doaj.art-3b1b4da8b0864ee0b1455e633f93fc6f |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-04-13T03:21:47Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-3b1b4da8b0864ee0b1455e633f93fc6f2022-12-22T03:04:46ZengElsevierData in Brief2352-34092017-04-0111C58859210.1016/j.dib.2017.03.002Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c backgroundVishal Singh0Beng San Yeoh1Marit Nilsen-Hamilton2Thorsten Berger3Tak W. Mak4Matam Vijay-Kumar5Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USADepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USADepartment of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USAThe Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada M5G 2C1The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada M5G 2C1Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USAThe data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.http://www.sciencedirect.com/science/article/pii/S2352340917300781SiderocalinNeutrophil gelatinase-associated lipocalinInflammatory bowel diseaseIL-10 |
| spellingShingle | Vishal Singh Beng San Yeoh Marit Nilsen-Hamilton Thorsten Berger Tak W. Mak Matam Vijay-Kumar Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background Data in Brief Siderocalin Neutrophil gelatinase-associated lipocalin Inflammatory bowel disease IL-10 |
| title | Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background |
| title_full | Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background |
| title_fullStr | Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background |
| title_full_unstemmed | Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background |
| title_short | Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background |
| title_sort | data on il 10r neutralization induced chronic colitis in lipocalin 2 deficient mice on balb c background |
| topic | Siderocalin Neutrophil gelatinase-associated lipocalin Inflammatory bowel disease IL-10 |
| url | http://www.sciencedirect.com/science/article/pii/S2352340917300781 |
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