Thermodynamic control of small RNA-mediated gene silencing

Thermodynamic control of small RNA-mediated gene silencing

Small interfering RNAs (siRNAs) and microRNAs (miRNAs) are crucial regulators of posttranscriptional gene silencing, which is referred to as RNA interference (RNAi) or RNA silencing. In RNAi, siRNA loaded onto the RNA-induced silencing complex (RISC) downregulates target gene expression by cleaving...

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Bibliographic Details
Main Authors: Kumiko eUi-Tei, Kenji eNishi, Tomoko eTakahashi, Tatsuya eNagasawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Genetics
Subjects:
RNAi
siRNA
off-target effect
thermodynamic stability
seed region
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00101/full

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