Tools for Molecular Epidemiology of <i>Streptococcus suis</i>
Diseases caused by <i>Streptococcus suis</i> are a significant economic and welfare concern in pigs as well as in humans. Several molecular methods have been applied to investigate <i>S. suis</i> strain diversity and identify phylogenetic groups. Multilocus sequence typing (M...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-01-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/9/2/81 |
| _version_ | 1811302115899867136 |
|---|---|
| author | Rujirat Hatrongjit Nahuel Fittipaldi Marcelo Gottschalk Anusak Kerdsin |
| author_facet | Rujirat Hatrongjit Nahuel Fittipaldi Marcelo Gottschalk Anusak Kerdsin |
| author_sort | Rujirat Hatrongjit |
| collection | DOAJ |
| description | Diseases caused by <i>Streptococcus suis</i> are a significant economic and welfare concern in pigs as well as in humans. Several molecular methods have been applied to investigate <i>S. suis</i> strain diversity and identify phylogenetic groups. Multilocus sequence typing (MLST), commonly used to differentiate between <i>S. suis</i> strains, has been instrumental in identifying that the species is genetically highly diverse. Recent advances in whole-genome analysis have resulted in schemes permitting the classification of <i>S. suis</i> populations as pathogenic or non-pathogenic, or disease-associated or non-disease associated. Here, we review these and other molecular approaches that can be used for surveillance, outbreak tracking, preventative health management, effective treatment and control, as well as vaccine development, including PCR based-assays that are easy to apply in modest diagnostic settings and which allow for the rapid screening of a large number of isolates at relatively low cost, granting the identification of several major clonal complexes of the <i>S. suis</i> population. |
| first_indexed | 2024-04-13T07:22:16Z |
| format | Article |
| id | doaj.art-3b1cb3f784d840b1bfa957cb45dadf66 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-13T07:22:16Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-3b1cb3f784d840b1bfa957cb45dadf662022-12-22T02:56:34ZengMDPI AGPathogens2076-08172020-01-01928110.3390/pathogens9020081pathogens9020081Tools for Molecular Epidemiology of <i>Streptococcus suis</i>Rujirat Hatrongjit0Nahuel Fittipaldi1Marcelo Gottschalk2Anusak Kerdsin3Department of General Sciences, Faculty of Science and Engineering, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, ThailandPublic Health Ontario, Toronto Laboratory, Toronto, ON M5G 1M1, CanadaFaculty of Veterinary Medicine, University of Montreal, Montreal, QC H3T 1J4, CanadaFaculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, ThailandDiseases caused by <i>Streptococcus suis</i> are a significant economic and welfare concern in pigs as well as in humans. Several molecular methods have been applied to investigate <i>S. suis</i> strain diversity and identify phylogenetic groups. Multilocus sequence typing (MLST), commonly used to differentiate between <i>S. suis</i> strains, has been instrumental in identifying that the species is genetically highly diverse. Recent advances in whole-genome analysis have resulted in schemes permitting the classification of <i>S. suis</i> populations as pathogenic or non-pathogenic, or disease-associated or non-disease associated. Here, we review these and other molecular approaches that can be used for surveillance, outbreak tracking, preventative health management, effective treatment and control, as well as vaccine development, including PCR based-assays that are easy to apply in modest diagnostic settings and which allow for the rapid screening of a large number of isolates at relatively low cost, granting the identification of several major clonal complexes of the <i>S. suis</i> population.https://www.mdpi.com/2076-0817/9/2/81<i>streptococcus suis</i>clonal complexmultilocus sequence typing (mlst)pcrminimum core genome sequence typing (mcg)pathotyping |
| spellingShingle | Rujirat Hatrongjit Nahuel Fittipaldi Marcelo Gottschalk Anusak Kerdsin Tools for Molecular Epidemiology of <i>Streptococcus suis</i> Pathogens <i>streptococcus suis</i> clonal complex multilocus sequence typing (mlst) pcr minimum core genome sequence typing (mcg) pathotyping |
| title | Tools for Molecular Epidemiology of <i>Streptococcus suis</i> |
| title_full | Tools for Molecular Epidemiology of <i>Streptococcus suis</i> |
| title_fullStr | Tools for Molecular Epidemiology of <i>Streptococcus suis</i> |
| title_full_unstemmed | Tools for Molecular Epidemiology of <i>Streptococcus suis</i> |
| title_short | Tools for Molecular Epidemiology of <i>Streptococcus suis</i> |
| title_sort | tools for molecular epidemiology of i streptococcus suis i |
| topic | <i>streptococcus suis</i> clonal complex multilocus sequence typing (mlst) pcr minimum core genome sequence typing (mcg) pathotyping |
| url | https://www.mdpi.com/2076-0817/9/2/81 |
| work_keys_str_mv | AT rujirathatrongjit toolsformolecularepidemiologyofistreptococcussuisi AT nahuelfittipaldi toolsformolecularepidemiologyofistreptococcussuisi AT marcelogottschalk toolsformolecularepidemiologyofistreptococcussuisi AT anusakkerdsin toolsformolecularepidemiologyofistreptococcussuisi |