Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis
Obstructive Sleep Apnoea (OSA) is characterized by a pro-oxidant state that results from the recurrent hypoxia-reoxygenation cycles. Superoxide dismutase (SOD), a key antioxidant enzyme involved in the detoxification of superoxide radicals, could represent a reliable marker to monitor the antioxidan...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/11/1764 |
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| author | Maria Carmina Pau Arduino Aleksander Mangoni Elisabetta Zinellu Gianfranco Pintus Ciriaco Carru Alessandro Giuseppe Fois Pietro Pirina Angelo Zinellu |
| author_facet | Maria Carmina Pau Arduino Aleksander Mangoni Elisabetta Zinellu Gianfranco Pintus Ciriaco Carru Alessandro Giuseppe Fois Pietro Pirina Angelo Zinellu |
| author_sort | Maria Carmina Pau |
| collection | DOAJ |
| description | Obstructive Sleep Apnoea (OSA) is characterized by a pro-oxidant state that results from the recurrent hypoxia-reoxygenation cycles. Superoxide dismutase (SOD), a key antioxidant enzyme involved in the detoxification of superoxide radicals, could represent a reliable marker to monitor the antioxidant defences in OSA. In order to capture and critically appraise the available evidence, we performed a systematic review and meta-analysis of studies reporting SOD concentrations in OSA patients and non-OSA controls in the electronic databases Pubmed, Web of Science, Scopus and Google Scholar. In total, 13 studies in 847 OSA patients and 438 non-OSA controls were included in the meta-analysis. Blood SOD concentrations were significantly lower in OSA patients (SMD = 0.87, <i>p</i> < 0.001). By contrast, serum/plasma SOD concentrations were not significantly different between the two groups. Although extreme between-study heterogeneity was observed, the SMD was not substantially modified when individual studies were sequentially removed. In conclusion, we observed that whole blood, but not serum/plasma, SOD concentrations were significantly lower in OSA patients compared with controls. Our meta-analysis suggests an impaired antioxidant defence in OSA that is more robustly assessed in the corpuscular biological matrix and provides useful background information for further studies investigating the association between SOD changes and clinical status in OSA. |
| first_indexed | 2024-03-10T05:44:59Z |
| format | Article |
| id | doaj.art-3b1d0025626b421aab8117f0c087b4a1 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:44:59Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3b1d0025626b421aab8117f0c087b4a12023-11-22T22:13:21ZengMDPI AGAntioxidants2076-39212021-11-011011176410.3390/antiox10111764Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-AnalysisMaria Carmina Pau0Arduino Aleksander Mangoni1Elisabetta Zinellu2Gianfranco Pintus3Ciriaco Carru4Alessandro Giuseppe Fois5Pietro Pirina6Angelo Zinellu7Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Clinical Pharmacology, Flinders University and Flinders Medical Centre, College of Medicine and Public Health, Bedford Park, SA 5042, AustraliaClinical and Interventional Pneumology, University Hospital Sassari (AOU), Viale San Pietro, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro, 07100 Sassari, ItalyDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro, 07100 Sassari, ItalyObstructive Sleep Apnoea (OSA) is characterized by a pro-oxidant state that results from the recurrent hypoxia-reoxygenation cycles. Superoxide dismutase (SOD), a key antioxidant enzyme involved in the detoxification of superoxide radicals, could represent a reliable marker to monitor the antioxidant defences in OSA. In order to capture and critically appraise the available evidence, we performed a systematic review and meta-analysis of studies reporting SOD concentrations in OSA patients and non-OSA controls in the electronic databases Pubmed, Web of Science, Scopus and Google Scholar. In total, 13 studies in 847 OSA patients and 438 non-OSA controls were included in the meta-analysis. Blood SOD concentrations were significantly lower in OSA patients (SMD = 0.87, <i>p</i> < 0.001). By contrast, serum/plasma SOD concentrations were not significantly different between the two groups. Although extreme between-study heterogeneity was observed, the SMD was not substantially modified when individual studies were sequentially removed. In conclusion, we observed that whole blood, but not serum/plasma, SOD concentrations were significantly lower in OSA patients compared with controls. Our meta-analysis suggests an impaired antioxidant defence in OSA that is more robustly assessed in the corpuscular biological matrix and provides useful background information for further studies investigating the association between SOD changes and clinical status in OSA.https://www.mdpi.com/2076-3921/10/11/1764obstructive sleep apnoeaoxidative stresssuperoxide dismutase |
| spellingShingle | Maria Carmina Pau Arduino Aleksander Mangoni Elisabetta Zinellu Gianfranco Pintus Ciriaco Carru Alessandro Giuseppe Fois Pietro Pirina Angelo Zinellu Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis Antioxidants obstructive sleep apnoea oxidative stress superoxide dismutase |
| title | Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis |
| title_full | Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis |
| title_fullStr | Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis |
| title_short | Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis |
| title_sort | circulating superoxide dismutase concentrations in obstructive sleep apnoea osa a systematic review and meta analysis |
| topic | obstructive sleep apnoea oxidative stress superoxide dismutase |
| url | https://www.mdpi.com/2076-3921/10/11/1764 |
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