Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities

Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities

Abstract Tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2) are two homologous proteins that are gaining increasing importance due to their implication in multiple pathways and diseases such as cancer. TNKS1/2 interact with a large variety of substrates through the ankyrin (ANK) domain, which recognizes a...

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Bibliographic Details
Main Authors:	Esteban Zamudio-Martinez, Ana Belén Herrera-Campos, Alberto Muñoz, José Manuel Rodríguez-Vargas, F. Javier Oliver
Format:	Article
Language:	English
Published:	BMC 2021-04-01
Series:	Journal of Experimental & Clinical Cancer Research
Subjects:	TNKS1/2 Tankyrase binding motif Proteasomal degradation Scaffolding function Cancer Inhibitors
Online Access:	https://doi.org/10.1186/s13046-021-01950-6

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