Identification of a Benzamide Derivative that Inhibits Stress-Induced Adrenal Corticosteroid Synthesis

Identification of a Benzamide Derivative that Inhibits Stress-Induced Adrenal Corticosteroid Synthesis

Elevated serum glucocorticoid levels contribute to the progression of many diseases, including depression, Alzheimer’s disease, hypertension, and acquired immunodeficiency syndrome. Here we show that the benzamide derivative N-[2-(4-cyclopropanecarbonyl-3-methyl-piperazin-1-yl)-1-(tert-butyl-1H-indo...

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Bibliographic Details
Main Authors: Jing Xu, Laurent Lecanu, Matthew Tan, Janet Greeson, Vassilios Papadopoulos
Format: Article
Language:English
Published: MDPI AG 2009-09-01
Series:Molecules
Subjects:
steroid synthesis
cholesterol uptake
cortisol
adrenal
neuroprotection
Online Access:http://www.mdpi.com/1420-3049/14/9/3392/

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