Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell Carcinoma
Kidney renal clear cell carcinoma (KIRC) has long been identified as a highly immune-infiltrated tumor. However, the underlying role of pyroptosis in the tumor microenvironment (TME) of KIRC remains poorly described. Herein, we systematically analyzed the prognostic value, role in the TME, response...
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| Format: | Article |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.716854/full |
| _version_ | 1819239906922201088 |
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| author | Zhuolun Sun Changying Jing Xudong Guo Mingxiao Zhang Feng Kong Zhenqing Wang Shaobo Jiang Hanbo Wang |
| author_facet | Zhuolun Sun Changying Jing Xudong Guo Mingxiao Zhang Feng Kong Zhenqing Wang Shaobo Jiang Hanbo Wang |
| author_sort | Zhuolun Sun |
| collection | DOAJ |
| description | Kidney renal clear cell carcinoma (KIRC) has long been identified as a highly immune-infiltrated tumor. However, the underlying role of pyroptosis in the tumor microenvironment (TME) of KIRC remains poorly described. Herein, we systematically analyzed the prognostic value, role in the TME, response to ICIs, and drug sensitivity of pyroptosis-related genes (PRGs) in KIRC patients based on The Cancer Genome Atlas (TCGA) database. Cluster 2, by consensus clustering for 24 PRGs, presented a poor prognosis, likely because malignancy-related hallmarks were remarkably enriched. Additionally, we constructed a prognostic prediction model that discriminated well between high- and low-risk patients and was further confirmed in external E-MTAB-1980 cohort and HSP cohort. By further analyzing the TME based on the risk model, higher immune cell infiltration and lower tumor purity were found in the high-risk group, which presented a poor prognosis. Patients with high risk scores also exhibited higher ICI expression, indicating that these patients may be more prone to profit from ICIs. The sensitivity to anticancer drugs that correlated with model-related genes was also identified. Collectively, the pyroptosis-related prognosis risk model may improve prognostic information and provide directions for current research investigations on immunotherapeutic strategies for KIRC patients. |
| first_indexed | 2024-12-23T13:59:34Z |
| format | Article |
| id | doaj.art-3b209eff89db4016bb7a2c84867f103e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T13:59:34Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3b209eff89db4016bb7a2c84867f103e2022-12-21T17:44:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-09-011110.3389/fonc.2021.716854716854Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell CarcinomaZhuolun Sun0Changying Jing1Xudong Guo2Mingxiao Zhang3Feng Kong4Zhenqing Wang5Shaobo Jiang6Hanbo Wang7Department of Urology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaSchool of Medicine, Technical University of Munich, Munich, GermanyDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaKidney renal clear cell carcinoma (KIRC) has long been identified as a highly immune-infiltrated tumor. However, the underlying role of pyroptosis in the tumor microenvironment (TME) of KIRC remains poorly described. Herein, we systematically analyzed the prognostic value, role in the TME, response to ICIs, and drug sensitivity of pyroptosis-related genes (PRGs) in KIRC patients based on The Cancer Genome Atlas (TCGA) database. Cluster 2, by consensus clustering for 24 PRGs, presented a poor prognosis, likely because malignancy-related hallmarks were remarkably enriched. Additionally, we constructed a prognostic prediction model that discriminated well between high- and low-risk patients and was further confirmed in external E-MTAB-1980 cohort and HSP cohort. By further analyzing the TME based on the risk model, higher immune cell infiltration and lower tumor purity were found in the high-risk group, which presented a poor prognosis. Patients with high risk scores also exhibited higher ICI expression, indicating that these patients may be more prone to profit from ICIs. The sensitivity to anticancer drugs that correlated with model-related genes was also identified. Collectively, the pyroptosis-related prognosis risk model may improve prognostic information and provide directions for current research investigations on immunotherapeutic strategies for KIRC patients.https://www.frontiersin.org/articles/10.3389/fonc.2021.716854/fullpyroptosiskidney renal clear cell carcinomatumor microenvironmentsurvival analysisprognostic model |
| spellingShingle | Zhuolun Sun Changying Jing Xudong Guo Mingxiao Zhang Feng Kong Zhenqing Wang Shaobo Jiang Hanbo Wang Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell Carcinoma Frontiers in Oncology pyroptosis kidney renal clear cell carcinoma tumor microenvironment survival analysis prognostic model |
| title | Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell Carcinoma |
| title_full | Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell Carcinoma |
| title_fullStr | Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell Carcinoma |
| title_full_unstemmed | Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell Carcinoma |
| title_short | Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell Carcinoma |
| title_sort | comprehensive analysis of the immune infiltrates of pyroptosis in kidney renal clear cell carcinoma |
| topic | pyroptosis kidney renal clear cell carcinoma tumor microenvironment survival analysis prognostic model |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.716854/full |
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