Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.
<h4>Purpose</h4>This study investigates physical performance limitations for sports and daily activities in recently diagnosed childhood cancer survivors and siblings.<h4>Methods</h4>The Swiss Childhood Cancer Survivor Study sent a questionnaire to all survivors (≥ 16 years)...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082232/pdf/?tool=EBI |
| _version_ | 1818460136853733376 |
|---|---|
| author | Corina S Rueegg Gisela Michel Laura Wengenroth Nicolas X von der Weid Eva Bergstraesser Claudia E Kuehni Swiss Paediatric Oncology Group (SPOG) |
| author_facet | Corina S Rueegg Gisela Michel Laura Wengenroth Nicolas X von der Weid Eva Bergstraesser Claudia E Kuehni Swiss Paediatric Oncology Group (SPOG) |
| author_sort | Corina S Rueegg |
| collection | DOAJ |
| description | <h4>Purpose</h4>This study investigates physical performance limitations for sports and daily activities in recently diagnosed childhood cancer survivors and siblings.<h4>Methods</h4>The Swiss Childhood Cancer Survivor Study sent a questionnaire to all survivors (≥ 16 years) registered in the Swiss Childhood Cancer Registry, who survived >5 years and were diagnosed 1976-2003 aged <16 years. Siblings received similar questionnaires. We assessed two types of physical performance limitations: 1) limitations in sports; 2) limitations in daily activities (using SF-36 physical function score). We compared results between survivors diagnosed before and after 1990 and determined predictors for both types of limitations by multivariable logistic regression.<h4>Results</h4>The sample included 1038 survivors and 534 siblings. Overall, 96 survivors (9.5%) and 7 siblings (1.1%) reported a limitation in sports (Odds ratio 5.5, 95%CI 2.9-10.4, p<0.001), mainly caused by musculoskeletal and neurological problems. Findings were even more pronounced for children diagnosed more recently (OR 4.8, CI 2.4-9.6 and 8.3, CI 3.7-18.8 for those diagnosed <1990 and ≥ 1990, respectively; p=0.025). Mean physical function score for limitations in daily activities was 49.6 (CI 48.9-50.4) in survivors and 53.1 (CI 52.5-53.7) in siblings (p<0.001). Again, differences tended to be larger in children diagnosed more recently. Survivors of bone tumors, CNS tumors and retinoblastoma and children treated with radiotherapy were most strongly affected.<h4>Conclusion</h4>Survivors of childhood cancer, even those diagnosed recently and treated with modern protocols, remain at high risk for physical performance limitations. Treatment and follow-up care should include tailored interventions to mitigate these late effects in high-risk patients. |
| first_indexed | 2024-12-14T23:25:27Z |
| format | Article |
| id | doaj.art-3b20b15db1c14a8eb778e29e91714219 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T23:25:27Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3b20b15db1c14a8eb778e29e917142192022-12-21T22:43:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4794410.1371/journal.pone.0047944Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.Corina S RueeggGisela MichelLaura WengenrothNicolas X von der WeidEva BergstraesserClaudia E KuehniSwiss Paediatric Oncology Group (SPOG)<h4>Purpose</h4>This study investigates physical performance limitations for sports and daily activities in recently diagnosed childhood cancer survivors and siblings.<h4>Methods</h4>The Swiss Childhood Cancer Survivor Study sent a questionnaire to all survivors (≥ 16 years) registered in the Swiss Childhood Cancer Registry, who survived >5 years and were diagnosed 1976-2003 aged <16 years. Siblings received similar questionnaires. We assessed two types of physical performance limitations: 1) limitations in sports; 2) limitations in daily activities (using SF-36 physical function score). We compared results between survivors diagnosed before and after 1990 and determined predictors for both types of limitations by multivariable logistic regression.<h4>Results</h4>The sample included 1038 survivors and 534 siblings. Overall, 96 survivors (9.5%) and 7 siblings (1.1%) reported a limitation in sports (Odds ratio 5.5, 95%CI 2.9-10.4, p<0.001), mainly caused by musculoskeletal and neurological problems. Findings were even more pronounced for children diagnosed more recently (OR 4.8, CI 2.4-9.6 and 8.3, CI 3.7-18.8 for those diagnosed <1990 and ≥ 1990, respectively; p=0.025). Mean physical function score for limitations in daily activities was 49.6 (CI 48.9-50.4) in survivors and 53.1 (CI 52.5-53.7) in siblings (p<0.001). Again, differences tended to be larger in children diagnosed more recently. Survivors of bone tumors, CNS tumors and retinoblastoma and children treated with radiotherapy were most strongly affected.<h4>Conclusion</h4>Survivors of childhood cancer, even those diagnosed recently and treated with modern protocols, remain at high risk for physical performance limitations. Treatment and follow-up care should include tailored interventions to mitigate these late effects in high-risk patients.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082232/pdf/?tool=EBI |
| spellingShingle | Corina S Rueegg Gisela Michel Laura Wengenroth Nicolas X von der Weid Eva Bergstraesser Claudia E Kuehni Swiss Paediatric Oncology Group (SPOG) Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings. PLoS ONE |
| title | Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings. |
| title_full | Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings. |
| title_fullStr | Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings. |
| title_full_unstemmed | Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings. |
| title_short | Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings. |
| title_sort | physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082232/pdf/?tool=EBI |
| work_keys_str_mv | AT corinasrueegg physicalperformancelimitationsinadolescentandadultsurvivorsofchildhoodcancerandtheirsiblings AT giselamichel physicalperformancelimitationsinadolescentandadultsurvivorsofchildhoodcancerandtheirsiblings AT laurawengenroth physicalperformancelimitationsinadolescentandadultsurvivorsofchildhoodcancerandtheirsiblings AT nicolasxvonderweid physicalperformancelimitationsinadolescentandadultsurvivorsofchildhoodcancerandtheirsiblings AT evabergstraesser physicalperformancelimitationsinadolescentandadultsurvivorsofchildhoodcancerandtheirsiblings AT claudiaekuehni physicalperformancelimitationsinadolescentandadultsurvivorsofchildhoodcancerandtheirsiblings AT swisspaediatriconcologygroupspog physicalperformancelimitationsinadolescentandadultsurvivorsofchildhoodcancerandtheirsiblings |