Associations of <i>APOE</i> Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia
The present study aimed to analyze possible associations of rs7412 and rs429358 of the <i>APOE</i> gene with lipid profile parameters, the risk of myocardial infarction, and death in the mostly white population of Western Siberia (Russia). The study population was selected from a sample...
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MDPI AG
2022-04-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/4/118 |
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| author | Sergey Semaev Elena Shakhtshneider Liliya Shcherbakova Dinara Ivanoshchuk Pavel Orlov Sophia Malyutina Valery Gafarov Yuliya Ragino Mikhail Voevoda |
| author_facet | Sergey Semaev Elena Shakhtshneider Liliya Shcherbakova Dinara Ivanoshchuk Pavel Orlov Sophia Malyutina Valery Gafarov Yuliya Ragino Mikhail Voevoda |
| author_sort | Sergey Semaev |
| collection | DOAJ |
| description | The present study aimed to analyze possible associations of rs7412 and rs429358 of the <i>APOE</i> gene with lipid profile parameters, the risk of myocardial infarction, and death in the mostly white population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 subjects, age 53.8 ± 7.0 years, males/females 50/50). PCR was conducted with fluorescence detection according to the TaqMan principle on a real-time PCR machine. The frequency of a minor allele (C) of rs429358 was 0.13, and the frequency of a minor allele (T) of rs7412 was 0.09. In our study, the woman with the rare ɛ1/ɛ4 genotype had substantial aberrations in blood lipid levels. In Kaplan–Meier curves, statistically significant differences were revealed in the prognosis of survival within the subgroup of females who had a myocardial infarction (<i>p</i> = 0.0006): the prognosis was worse for carriers of the ɛ2/ɛ2 genotype and for ɛ4/ɛ4 carriers. Survival analysis regarding deaths from all causes showed (<i>p</i> = 0.0238) that female carriers of the ɛ2/ɛ4 genotype had a worse prognosis than did carriers of other genotypes. Thus, in the population of Western Siberia (Russia), we confirmed statistically significant associations between rs7412 & rs429358 genotypes and lipid profile parameters. |
| first_indexed | 2024-03-09T10:59:58Z |
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| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T10:59:58Z |
| publishDate | 2022-04-01 |
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| series | Current Issues in Molecular Biology |
| spelling | doaj.art-3b21265564fa468ca6a7f094671c440a2023-12-01T01:21:02ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-04-014441713172410.3390/cimb44040118Associations of <i>APOE</i> Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western SiberiaSergey Semaev0Elena Shakhtshneider1Liliya Shcherbakova2Dinara Ivanoshchuk3Pavel Orlov4Sophia Malyutina5Valery Gafarov6Yuliya Ragino7Mikhail Voevoda8Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaInstitute of Internal and Preventive Medicine (IIPM)—Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., 630089 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaInstitute of Internal and Preventive Medicine (IIPM)—Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., 630089 Novosibirsk, RussiaInstitute of Internal and Preventive Medicine (IIPM)—Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., 630089 Novosibirsk, RussiaInstitute of Internal and Preventive Medicine (IIPM)—Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., 630089 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaThe present study aimed to analyze possible associations of rs7412 and rs429358 of the <i>APOE</i> gene with lipid profile parameters, the risk of myocardial infarction, and death in the mostly white population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 subjects, age 53.8 ± 7.0 years, males/females 50/50). PCR was conducted with fluorescence detection according to the TaqMan principle on a real-time PCR machine. The frequency of a minor allele (C) of rs429358 was 0.13, and the frequency of a minor allele (T) of rs7412 was 0.09. In our study, the woman with the rare ɛ1/ɛ4 genotype had substantial aberrations in blood lipid levels. In Kaplan–Meier curves, statistically significant differences were revealed in the prognosis of survival within the subgroup of females who had a myocardial infarction (<i>p</i> = 0.0006): the prognosis was worse for carriers of the ɛ2/ɛ2 genotype and for ɛ4/ɛ4 carriers. Survival analysis regarding deaths from all causes showed (<i>p</i> = 0.0238) that female carriers of the ɛ2/ɛ4 genotype had a worse prognosis than did carriers of other genotypes. Thus, in the population of Western Siberia (Russia), we confirmed statistically significant associations between rs7412 & rs429358 genotypes and lipid profile parameters.https://www.mdpi.com/1467-3045/44/4/118rs7412rs429358risk of myocardial infarctionrisk of deathlipid profilewhite population |
| spellingShingle | Sergey Semaev Elena Shakhtshneider Liliya Shcherbakova Dinara Ivanoshchuk Pavel Orlov Sophia Malyutina Valery Gafarov Yuliya Ragino Mikhail Voevoda Associations of <i>APOE</i> Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia Current Issues in Molecular Biology rs7412 rs429358 risk of myocardial infarction risk of death lipid profile white population |
| title | Associations of <i>APOE</i> Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia |
| title_full | Associations of <i>APOE</i> Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia |
| title_fullStr | Associations of <i>APOE</i> Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia |
| title_full_unstemmed | Associations of <i>APOE</i> Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia |
| title_short | Associations of <i>APOE</i> Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia |
| title_sort | associations of i apoe i gene variants rs429358 and rs7412 with parameters of the blood lipid profile and the risk of myocardial infarction and death in a white population of western siberia |
| topic | rs7412 rs429358 risk of myocardial infarction risk of death lipid profile white population |
| url | https://www.mdpi.com/1467-3045/44/4/118 |
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