$Combined Single Nucleotide Variants of <i>ORAI1</i> and <i>BLK</i> in a Child with Refractory Kawasaki Disease$

Combined Single Nucleotide Variants of <i>ORAI1</i> and <i>BLK</i> in a Child with Refractory Kawasaki Disease

Kawasaki disease (KD) is a systemic vasculitis with an unknown etiology affecting young children. Although intravenous immunoglobulin (IVIG) plus acetylsalicylic acid is effective in most cases, approximately 10–20% of patients do not respond to this therapy. An 8-month-old boy was admitted to a loc...

Full description

Bibliographic Details
Main Authors:	Saki Kanda, Yoshimitsu Fujii, Shin-ichiro Hori, Taichi Ohmachi, Ken Yoshimura, Koichiro Higasa, Kazunari Kaneko
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Children
Subjects:	<i>BLK</i> cyclosporine A <i>ORAI1</i> refractory Kawasaki disease single nucleotide variant
Online Access:	https://www.mdpi.com/2227-9067/8/6/433

Similar Items

IgA Vasculitis: Influence of <i>CD40, BLK</i> and <i>BANK1</i> Gene Polymorphisms
by: Joao Carlos Batista Liz, et al.
Published: (2022-09-01)

Fever and rash: It can be Kawasaki disease
by: Bhardwaj Parveen, et al.
Published: (2009-01-01)

Long-Term Hypermethylation of <i>FcγR2B</i> in Leukocytes of Patients with Kawasaki Disease
by: Ling-Sai Chang, et al.
Published: (2021-05-01)

The Number and Position of Orai3 Units within Heteromeric Store-Operated Ca<sup>2+</sup> Channels Alter the Pharmacology of I<sub>CRAC</sub>
by: Sven Kappel, et al.
Published: (2020-04-01)

Dysbiosis of the gut microbiota as a susceptibility factor for Kawasaki disease
by: Yoshiki Teramoto, et al.
Published: (2023-10-01)

Cyclosporine Affects the Main Virulence Factors of <i>Cryptococcus neoformans</i> In Vitro
by: Iara Bastos de Andrade, et al.
Published: (2023-04-01)

The novel antitumor compound clinopodiside A induces cytotoxicity via autophagy mediated by the signaling of BLK and RasGRP2 in T24 bladder cancer cells
by: Rong Sheng Zhou, et al.
Published: (2022-09-01)

Interaction analysis between BLK rs13277113 polymorphism and BANK1 rs3733197 polymorphism, MMEL1/TNFRSF14 rs3890745 polymorphism in determining susceptibility to rheumatoid arthritis
by: Hua Huang, et al.
Published: (2017-10-01)

YOUTH EMPOWERMENT THROUGH THE BASIC MECHANICAL ENGINEERING EDUCATION AND TRAINING PROGRAM (DIKLAT) AT THE HADAIDA TECHNICAL CENTER BEKASI JOB TRAINING CENTER
by: Muhammad Hanif, et al.
Published: (2022-08-01)

The Effect of Cyclosporin A on <i>Aspergillus niger</i> and the Possible Mechanisms Involved
by: Fengming Li, et al.
Published: (2023-01-01)

Cyclosporin A as a Potential Insecticide to Control the Asian Corn Borer <i>Ostrinia furnacalis</i> Guenée (Lepidoptera: Pyralidae)
by: Chengxian Sun, et al.
Published: (2022-10-01)

Anti-Inflammatory Effects of Alphitolic Acid Isolated from <i>Agrimonia coreana</i> Nakai Extracts Are Mediated via the Inhibition of I<sub>CRAC</sub> Activity in T Cells
by: Su Jin Park, et al.
Published: (2023-12-01)

Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen <i>Aspergillus fumigatus</i>
by: Praveen R. Juvvadi, et al.
Published: (2022-12-01)

Can AI Help Pediatricians? Diagnosing Kawasaki Disease Using DRSA
by: Bartosz Siewert, et al.
Published: (2021-10-01)

Role of Orai3 in the Pathophysiology of Cancer
by: Jose Sanchez-Collado, et al.
Published: (2021-10-01)

ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses
by: Iman Azimi, et al.
Published: (2019-02-01)

Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β
by: Isaac Jardin, et al.
Published: (2022-11-01)

Loss of BLK expression as a potential predictor of poor prognosis and immune checkpoint blockade response in NSCLC and contribute to tumor progression
by: Yingqi Xu, et al.
Published: (2023-07-01)

Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
by: Scott M Emrich, et al.
Published: (2023-02-01)

As falas gravadas pelos outros: fontes orais, arquivos orais e arquivos sonoros, inquietações da história do tempo presente
by: Viviane Trindade Borges
Published: (2017-03-01)

As falas gravadas pelos outros: fontes orais, arquivos orais e arquivos sonoros, inquietações da história do tempo presente
by: Viviane Trindade Borges
Published: (2017-03-01)

Fixed Points of (<i>α</i>, <i>β</i>, <i>F</i>*) and (<i>α</i>, <i>β</i>, <i>F</i>**)-Weak Geraghty Contractions with an Application
by: Khairul Habib Alam, et al.
Published: (2023-01-01)

Prevalence and Genetic Diversity of Staphylococcal Enterotoxin (-Like) Genes <i>sey</i>, <i>selw</i>, <i>selx</i>, <i>selz</i>, <i>sel26</i> and <i>sel27</i> in Community-Acquired Methicillin-Resistant <i>Staphylococcus aureus</i>
by: Meiji Soe Aung, et al.
Published: (2020-05-01)

On (<i>p</i>, <i>q</i>)-Sine and (<i>p</i>, <i>q</i>)-Cosine Fubini Polynomials
by: Waseem Ahmad Khan, et al.
Published: (2022-03-01)

Pollen morphology of <i>Curroria</i>, <i>Mondia</i>, <i>Socotranthus</i> and <i>Stomatostemma</i> (Periplocaceae)
by: R. L. Verhoeven, et al.
Published: (1993-10-01)

The Phytochemistry and Pharmacology of <i>Tulbaghia</i>, <i>Allium</i>, <i>Crinum</i> and <i>Cyrtanthus</i>: ‘Talented’ Taxa from the Amaryllidaceae
by: Cynthia Amaning Danquah, et al.
Published: (2022-07-01)

Vitamin D Receptor (<i>VDR</i>) Genetic Variants: Relationship of <i>FokI</i> Genotypes with <i>VDR</i> Expression and Clinical Disease Activity in Systemic Lupus Erythematosus Patients
by: Mónica R. Meza-Meza, et al.
Published: (2022-11-01)

Illuminating a Truth: <i>Dṛṣṭānta</i> and <i>Huatou</i>
by: Jeson Woo
Published: (2020-08-01)

Development of an <i>Aus</i>-Derived Nested Association Mapping (<i>Aus</i>-NAM) Population in Rice
by: Justine K. Kitony, et al.
Published: (2021-06-01)

Distinct Effects of Immunosuppressive Drugs on the Anti-<i>Aspergillus</i> Activity of Human Natural Killer Cells
by: Stanislaw Schmidt, et al.
Published: (2019-11-01)

<i>Rickettsiales</i> in Italy
by: Cristoforo Guccione, et al.
Published: (2021-02-01)

Development of a Multiplex Droplet Digital PCR Assay for the Detection of <i>Babesia</i>, <i>Bartonella</i>, and <i>Borrelia</i> Species
by: Ricardo Maggi, et al.
Published: (2021-11-01)

<i>CRKL</i>, <i>AIFM3</i>, <i>AIF</i>, <i>BCL2</i>, and <i>UBASH3A</i> during Human Kidney Development
by: Mirela Lozic, et al.
Published: (2021-08-01)

Transmission of <i>Grapevine leafroll-associated virus-1</i> (<i>Ampelovirus</i>) and <i>Grapevine virus A</i> (<i>Vitivirus</i>) by the Cottony Grape Scale, <i>Pulvinaria vitis</i> (Hemiptera: <i>Coccidae</i>)
by: Gérard Hommay, et al.
Published: (2021-10-01)

Additions to The Knowledge of <i>Tubakia</i> (<i>Tubakiaceae</i>, <i>Diaporthales</i>) in China
by: Ya-Quan Zhu, et al.
Published: (2022-10-01)

Overexpression of Rice <i>BSR2</i> Confers Disease Resistance and Induces Enlarged Flowers in <i>Torenia fournieri</i> Lind
by: Satoru Maeda, et al.
Published: (2022-04-01)

Metric <i>f</i>-Contact Manifolds Satisfying the (<i>κ</i>, <i>μ</i>)-Nullity Condition
by: Alfonso Carriazo, et al.
Published: (2020-06-01)

Statins Show Anti-Atherosclerotic Effects by Improving Endothelial Cell Function in a Kawasaki Disease-like Vasculitis Mouse Model
by: Yusuke Motoji, et al.
Published: (2022-12-01)

The Role of DNA Repair (<i>XPC</i>, <i>XPD</i>, <i>XPF</i>, and <i>XPG)</i> Gene Polymorphisms in the Development of Myeloproliferative Neoplasms
by: Adriana-Stela Crișan, et al.
Published: (2024-03-01)

A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite <i>Trypanosoma Cruzi</i>
by: Alina E. Perrone, et al.
Published: (2018-10-01)