Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids
Autism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders that affect communication and social interactions and present with restricted interests and repetitive behavior patterns. The susceptibility to ASD is strongly influenced by genetic/heritable factors; however, there...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/2/260 |
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| author | John Lenon de Souza Santos Cecília de Almeida Araújo Clarissa Araújo Gurgel Rocha Zaquer Suzana Munhoz Costa-Ferro Bruno Solano de Freitas Souza |
| author_facet | John Lenon de Souza Santos Cecília de Almeida Araújo Clarissa Araújo Gurgel Rocha Zaquer Suzana Munhoz Costa-Ferro Bruno Solano de Freitas Souza |
| author_sort | John Lenon de Souza Santos |
| collection | DOAJ |
| description | Autism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders that affect communication and social interactions and present with restricted interests and repetitive behavior patterns. The susceptibility to ASD is strongly influenced by genetic/heritable factors; however, there is still a large gap in understanding the cellular and molecular mechanisms underlying the neurobiology of ASD. Significant progress has been made in identifying ASD risk genes and the possible convergent pathways regulated by these gene networks during development. The breakthrough of cellular reprogramming technology has allowed the generation of induced pluripotent stem cells (iPSCs) from individuals with syndromic and idiopathic ASD, providing patient-specific cell models for mechanistic studies. In the past decade, protocols for developing brain organoids from these cells have been established, leading to significant advances in the in vitro reproducibility of the early steps of human brain development. Here, we reviewed the most relevant literature regarding the application of brain organoids to the study of ASD, providing the current state of the art, and discussing the impact of such models on the field, limitations, and opportunities for future development. |
| first_indexed | 2024-03-11T09:05:47Z |
| format | Article |
| id | doaj.art-3b21ce0ebdcf42f28bda8a91d58a7a95 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T09:05:47Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3b21ce0ebdcf42f28bda8a91d58a7a952023-11-16T19:22:38ZengMDPI AGBiomolecules2218-273X2023-01-0113226010.3390/biom13020260Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain OrganoidsJohn Lenon de Souza Santos0Cecília de Almeida Araújo1Clarissa Araújo Gurgel Rocha2Zaquer Suzana Munhoz Costa-Ferro3Bruno Solano de Freitas Souza4Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador 40296-710, BrazilCenter for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador 41253-190, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador 40296-710, BrazilCenter for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador 41253-190, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador 40296-710, BrazilAutism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders that affect communication and social interactions and present with restricted interests and repetitive behavior patterns. The susceptibility to ASD is strongly influenced by genetic/heritable factors; however, there is still a large gap in understanding the cellular and molecular mechanisms underlying the neurobiology of ASD. Significant progress has been made in identifying ASD risk genes and the possible convergent pathways regulated by these gene networks during development. The breakthrough of cellular reprogramming technology has allowed the generation of induced pluripotent stem cells (iPSCs) from individuals with syndromic and idiopathic ASD, providing patient-specific cell models for mechanistic studies. In the past decade, protocols for developing brain organoids from these cells have been established, leading to significant advances in the in vitro reproducibility of the early steps of human brain development. Here, we reviewed the most relevant literature regarding the application of brain organoids to the study of ASD, providing the current state of the art, and discussing the impact of such models on the field, limitations, and opportunities for future development.https://www.mdpi.com/2218-273X/13/2/260brain organoidsautism spectrum disorderpluripotent stem cell |
| spellingShingle | John Lenon de Souza Santos Cecília de Almeida Araújo Clarissa Araújo Gurgel Rocha Zaquer Suzana Munhoz Costa-Ferro Bruno Solano de Freitas Souza Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids Biomolecules brain organoids autism spectrum disorder pluripotent stem cell |
| title | Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids |
| title_full | Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids |
| title_fullStr | Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids |
| title_full_unstemmed | Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids |
| title_short | Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids |
| title_sort | modeling autism spectrum disorders with induced pluripotent stem cell derived brain organoids |
| topic | brain organoids autism spectrum disorder pluripotent stem cell |
| url | https://www.mdpi.com/2218-273X/13/2/260 |
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