Otostegia persica extraction on healing process of burn wounds
PURPOSE: To investigate if the methanolic extract of the Otostegia persica can accelerating healing process of burn wound because of its anti-inflammatory and antioxidant effects. METHODS:Forty eight male Wistar rats were randomized into three study groups of 16 rats each. Burn wounds were created o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2013-06-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000600001 |
| _version_ | 1819001382099746816 |
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| author | Amin Ganjali Amir Sotoudeh Amirali Jahanshahi Mohammad Ashrafzadeh Takhtfooladi Ali Bazzazan Nasim Roodbari Maryam Pourramezani Harati |
| author_facet | Amin Ganjali Amir Sotoudeh Amirali Jahanshahi Mohammad Ashrafzadeh Takhtfooladi Ali Bazzazan Nasim Roodbari Maryam Pourramezani Harati |
| author_sort | Amin Ganjali |
| collection | DOAJ |
| description | PURPOSE: To investigate if the methanolic extract of the Otostegia persica can accelerating healing process of burn wound because of its anti-inflammatory and antioxidant effects. METHODS:Forty eight male Wistar rats were randomized into three study groups of 16 rats each. Burn wounds were created on dorsal part of shaved rats using a metal rod. In group I the burn wound was left without any treatment. Group was treated with topical silver sulfadiazine pomade. In group III, ointment containing the OP extract was administered. Skin biopsies were harvested from burn area on the 3rd, 5th, 14th and 21st days after burn and examined histologically. RESULTS: Re-epithelialization in the control group and in group II was lower than in group III. Re-epithelialization in groups II and III was significantly different from that in the control group. On the 5th day of the experiment, we assessed lower inflammation in the burn area compared to control group. This means that the inflammation was suppressed by methanolic extract of OP. From day 5 to 14; the fibroblast proliferation peaked and was associated with increased collagen accumulation. It was obvious that angiogenesis improved more in the groups II and III, which facilitated re-epithelialisation. CONCLUSION:Methanolic extract of Otostegia persica exhibited significant healing activity when topically applied on rats. OP is an effective treatment for saving the burn site. |
| first_indexed | 2024-12-20T22:48:19Z |
| format | Article |
| id | doaj.art-3b21dd8cb0974794b4c6053cdd0d8c14 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 1678-2674 |
| language | English |
| last_indexed | 2024-12-20T22:48:19Z |
| publishDate | 2013-06-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-3b21dd8cb0974794b4c6053cdd0d8c142022-12-21T19:24:18ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86501678-26742013-06-01286407411Otostegia persica extraction on healing process of burn woundsAmin GanjaliAmir SotoudehAmirali JahanshahiMohammad Ashrafzadeh TakhtfooladiAli BazzazanNasim RoodbariMaryam Pourramezani HaratiPURPOSE: To investigate if the methanolic extract of the Otostegia persica can accelerating healing process of burn wound because of its anti-inflammatory and antioxidant effects. METHODS:Forty eight male Wistar rats were randomized into three study groups of 16 rats each. Burn wounds were created on dorsal part of shaved rats using a metal rod. In group I the burn wound was left without any treatment. Group was treated with topical silver sulfadiazine pomade. In group III, ointment containing the OP extract was administered. Skin biopsies were harvested from burn area on the 3rd, 5th, 14th and 21st days after burn and examined histologically. RESULTS: Re-epithelialization in the control group and in group II was lower than in group III. Re-epithelialization in groups II and III was significantly different from that in the control group. On the 5th day of the experiment, we assessed lower inflammation in the burn area compared to control group. This means that the inflammation was suppressed by methanolic extract of OP. From day 5 to 14; the fibroblast proliferation peaked and was associated with increased collagen accumulation. It was obvious that angiogenesis improved more in the groups II and III, which facilitated re-epithelialisation. CONCLUSION:Methanolic extract of Otostegia persica exhibited significant healing activity when topically applied on rats. OP is an effective treatment for saving the burn site.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000600001Otostegia persicaBurnAntioxidantsRats |
| spellingShingle | Amin Ganjali Amir Sotoudeh Amirali Jahanshahi Mohammad Ashrafzadeh Takhtfooladi Ali Bazzazan Nasim Roodbari Maryam Pourramezani Harati Otostegia persica extraction on healing process of burn wounds Acta Cirúrgica Brasileira Otostegia persica Burn Antioxidants Rats |
| title | Otostegia persica extraction on healing process of burn wounds |
| title_full | Otostegia persica extraction on healing process of burn wounds |
| title_fullStr | Otostegia persica extraction on healing process of burn wounds |
| title_full_unstemmed | Otostegia persica extraction on healing process of burn wounds |
| title_short | Otostegia persica extraction on healing process of burn wounds |
| title_sort | otostegia persica extraction on healing process of burn wounds |
| topic | Otostegia persica Burn Antioxidants Rats |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000600001 |
| work_keys_str_mv | AT aminganjali otostegiapersicaextractiononhealingprocessofburnwounds AT amirsotoudeh otostegiapersicaextractiononhealingprocessofburnwounds AT amiralijahanshahi otostegiapersicaextractiononhealingprocessofburnwounds AT mohammadashrafzadehtakhtfooladi otostegiapersicaextractiononhealingprocessofburnwounds AT alibazzazan otostegiapersicaextractiononhealingprocessofburnwounds AT nasimroodbari otostegiapersicaextractiononhealingprocessofburnwounds AT maryampourramezaniharati otostegiapersicaextractiononhealingprocessofburnwounds |