Solubility of Gallic Acid in Single and Mixed Solvents
Gallic acid, known for its biological activity contributing to human health, including antioxidant, anti-inflammatory, anticancer, and antimutagenic properties, was the focus of this study. The solubility of gallic acid was experimentally measured in pure and mixed solvents of water, ethanol, and ac...
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MDPI AG
2024-01-01
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| Online Access: | https://www.mdpi.com/2297-8739/11/1/36 |
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| author | Yea-Rok Park Bong-Seop Lee |
| author_facet | Yea-Rok Park Bong-Seop Lee |
| author_sort | Yea-Rok Park |
| collection | DOAJ |
| description | Gallic acid, known for its biological activity contributing to human health, including antioxidant, anti-inflammatory, anticancer, and antimutagenic properties, was the focus of this study. The solubility of gallic acid was experimentally measured in pure and mixed solvents of water, ethanol, and acetic acid and predicted using the COSMO-SAC model and the Hansen solubility parameter. The Hansen solubility parameter method predicted a higher solubility of gallic acid in pure water than in pure ethanol, and in a mixed solvent, it predicted the maximum solubility at 80% water content, showing different results from the experimental data trends. However, using the molar volume obtained from COSMO calculations resulted in a tendency that matched the experimental results. The results revealed higher solubility in ethanol compared to water, with the solubility in mixed solvent falling within the range between them. Using the same method, the Hansen solubility parameter obtained was applied to acetic acid/water and acetic acid/ethanol mixtures, and similar trends were observed compared to experimental data. In particular, gallic acid in the acetic acid/water mixture solvent exhibited maximum solubility, and this phenomenon was well-predicted. As the temperature increased, solubility in both pure and mixed solvents also increased. While the COSMO-SAC model effectively captured this trend, the predicted solubility values were slightly lower than the experimental data. The solubility trends depending on solvent types were confirmed by comparing the σ-profiles of each compound. The σ-profile of gallic acid closely resembled that of ethanol, and this result led to higher solubility than water and acetic acid. The maximum solubility in ethanol/water and acetic acid/water mixed solvents could be anticipated when two solvents with significant differences in their σ-profiles are mixed in an appropriate ratio. |
| first_indexed | 2024-03-08T10:35:16Z |
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| issn | 2297-8739 |
| language | English |
| last_indexed | 2024-03-08T10:35:16Z |
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| spelling | doaj.art-3b226ef85e714ffc8c76362e233200122024-01-26T18:27:30ZengMDPI AGSeparations2297-87392024-01-011113610.3390/separations11010036Solubility of Gallic Acid in Single and Mixed SolventsYea-Rok Park0Bong-Seop Lee1Department of Chemical Engineering, Kangwon National University, Chuncheon 24341, Republic of KoreaDepartment of Chemical Engineering, Kangwon National University, Chuncheon 24341, Republic of KoreaGallic acid, known for its biological activity contributing to human health, including antioxidant, anti-inflammatory, anticancer, and antimutagenic properties, was the focus of this study. The solubility of gallic acid was experimentally measured in pure and mixed solvents of water, ethanol, and acetic acid and predicted using the COSMO-SAC model and the Hansen solubility parameter. The Hansen solubility parameter method predicted a higher solubility of gallic acid in pure water than in pure ethanol, and in a mixed solvent, it predicted the maximum solubility at 80% water content, showing different results from the experimental data trends. However, using the molar volume obtained from COSMO calculations resulted in a tendency that matched the experimental results. The results revealed higher solubility in ethanol compared to water, with the solubility in mixed solvent falling within the range between them. Using the same method, the Hansen solubility parameter obtained was applied to acetic acid/water and acetic acid/ethanol mixtures, and similar trends were observed compared to experimental data. In particular, gallic acid in the acetic acid/water mixture solvent exhibited maximum solubility, and this phenomenon was well-predicted. As the temperature increased, solubility in both pure and mixed solvents also increased. While the COSMO-SAC model effectively captured this trend, the predicted solubility values were slightly lower than the experimental data. The solubility trends depending on solvent types were confirmed by comparing the σ-profiles of each compound. The σ-profile of gallic acid closely resembled that of ethanol, and this result led to higher solubility than water and acetic acid. The maximum solubility in ethanol/water and acetic acid/water mixed solvents could be anticipated when two solvents with significant differences in their σ-profiles are mixed in an appropriate ratio.https://www.mdpi.com/2297-8739/11/1/36gallic acidsolubilitymixed solventHansen solubility parameterCOSMO-SAC |
| spellingShingle | Yea-Rok Park Bong-Seop Lee Solubility of Gallic Acid in Single and Mixed Solvents Separations gallic acid solubility mixed solvent Hansen solubility parameter COSMO-SAC |
| title | Solubility of Gallic Acid in Single and Mixed Solvents |
| title_full | Solubility of Gallic Acid in Single and Mixed Solvents |
| title_fullStr | Solubility of Gallic Acid in Single and Mixed Solvents |
| title_full_unstemmed | Solubility of Gallic Acid in Single and Mixed Solvents |
| title_short | Solubility of Gallic Acid in Single and Mixed Solvents |
| title_sort | solubility of gallic acid in single and mixed solvents |
| topic | gallic acid solubility mixed solvent Hansen solubility parameter COSMO-SAC |
| url | https://www.mdpi.com/2297-8739/11/1/36 |
| work_keys_str_mv | AT yearokpark solubilityofgallicacidinsingleandmixedsolvents AT bongseoplee solubilityofgallicacidinsingleandmixedsolvents |