Differential Genome Replication of a Unique Single-Amino-Acid Mutation in the Adenovirus-4 Component of the Live Oral Adenovirus Type 4 and Type 7 Vaccine

Differential Genome Replication of a Unique Single-Amino-Acid Mutation in the Adenovirus-4 Component of the Live Oral Adenovirus Type 4 and Type 7 Vaccine

The FDA-approved Adenovirus Type 4 and Type 7 Vaccine, Live, Oral is highly effective and essential in preventing acute respiratory diseases (ARDs) in U.S. military recruits. Our study revealed the presence of a previously undetected mutation, not found in the wild-type human adenovirus type 4 (HAdV...

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Bibliographic Details
Main Authors: Natalie D. Collins, Shannon Beaty, Elana Wallace, Yuanzhang Li, Mark Sanborn, Yu Yang, Anima Adhikari, Paul Shabram, Kelly Warfield, Nicos Karasavvas, Robert A. Kuschner, Jun Hang
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Vaccines
Subjects:
adenovirus
HAdV-4
DNA virus
vaccine
replication
mutation
Online Access:https://www.mdpi.com/2076-393X/11/7/1144

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