TRIB3 Modulates PPARγ-Mediated Growth Inhibition by Interfering with the MLL Complex in Breast Cancer Cells

TRIB3 Modulates PPARγ-Mediated Growth Inhibition by Interfering with the MLL Complex in Breast Cancer Cells

Aberrant expression or activity of proteins are amongst the best understood mechanisms that can drive cancer initiation and progression, as well as therapy resistance. TRIB3, a member of the Tribbles family of pseudokinases, is often dysregulated in cancer and has been associated with breast cancer...

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Bibliographic Details
Main Authors: Miguel Hernández-Quiles, Rosalie Baak, Alba Orea-Soufi, Anouska Borgman, Suzanne den Haan, Paula Sobrevals Alcaraz, Aldo Jongejan, Robert van Es, Guillermo Velasco, Harmjan Vos, Eric Kalkhoven
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
Tribbles
breast cancer
PPARγ
epigenetics
MLL–WRAD complex
Online Access:https://www.mdpi.com/1422-0067/23/18/10535

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