Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of macrophages?
<p>Abstract</p> <p>Breast carcinoma with osteoclastic giant cells (OGCs) is characterized by multinucleated OGCs, and usually displays inflammatory hypervascular stroma. OGCs may derive from tumor-associated macrophages, but their nature remains controversial. We report two cases,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-08-01
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| Series: | Diagnostic Pathology |
| Online Access: | http://www.diagnosticpathology.org/content/5/1/55 |
| _version_ | 1818473530644234240 |
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| author | Shishido-Hara Yukiko Kurata Atsushi Fujiwara Masachika Itoh Hiroki Imoto Shigeru Kamma Hiroshi |
| author_facet | Shishido-Hara Yukiko Kurata Atsushi Fujiwara Masachika Itoh Hiroki Imoto Shigeru Kamma Hiroshi |
| author_sort | Shishido-Hara Yukiko |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Breast carcinoma with osteoclastic giant cells (OGCs) is characterized by multinucleated OGCs, and usually displays inflammatory hypervascular stroma. OGCs may derive from tumor-associated macrophages, but their nature remains controversial. We report two cases, in which OGCs appear in common microenvironment despite different tumoural histology. A 44-year-old woman (Case 1) had OGCs accompanying invasive ductal carcinoma, and an 83-year-old woman (Case 2) with carcinosarcoma. Immunohistochemically, in both cases, tumoural and non-tumoural cells strongly expressed VEGF and MMP12, which promote macrophage migration and angiogenesis. The Chalkley count on CD-31-stained sections revealed elevated angiogenesis in both cases. The OGCs expressed bone-osteoclast markers (MMP9, TRAP, cathepsin K) and a histiocyte marker (CD68), but not an MHC class II antigen, HLA-DR. The results indicate a pathogenesis: regardless of tumoural histology, OGCs derive from macrophages, likely in response to hypervascular microenvironments with secretion of common cytokines. The OGCs have acquired bone-osteoclast-like characteristics, but lost antigen presentation abilities as an anti-cancer defense. Appearance of OGCs may not be anti-tumoural immunological reactions, but rather pro-tumoural differentiation of macrophage responding to hypervascular microenvironments induced by breast cancer.</p> |
| first_indexed | 2024-04-14T04:24:59Z |
| format | Article |
| id | doaj.art-3b25b52a04f14ea3a42fe3ca1dad92c4 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-04-14T04:24:59Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-3b25b52a04f14ea3a42fe3ca1dad92c42022-12-22T02:12:21ZengBMCDiagnostic Pathology1746-15962010-08-01515510.1186/1746-1596-5-55Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of macrophages?Shishido-Hara YukikoKurata AtsushiFujiwara MasachikaItoh HirokiImoto ShigeruKamma Hiroshi<p>Abstract</p> <p>Breast carcinoma with osteoclastic giant cells (OGCs) is characterized by multinucleated OGCs, and usually displays inflammatory hypervascular stroma. OGCs may derive from tumor-associated macrophages, but their nature remains controversial. We report two cases, in which OGCs appear in common microenvironment despite different tumoural histology. A 44-year-old woman (Case 1) had OGCs accompanying invasive ductal carcinoma, and an 83-year-old woman (Case 2) with carcinosarcoma. Immunohistochemically, in both cases, tumoural and non-tumoural cells strongly expressed VEGF and MMP12, which promote macrophage migration and angiogenesis. The Chalkley count on CD-31-stained sections revealed elevated angiogenesis in both cases. The OGCs expressed bone-osteoclast markers (MMP9, TRAP, cathepsin K) and a histiocyte marker (CD68), but not an MHC class II antigen, HLA-DR. The results indicate a pathogenesis: regardless of tumoural histology, OGCs derive from macrophages, likely in response to hypervascular microenvironments with secretion of common cytokines. The OGCs have acquired bone-osteoclast-like characteristics, but lost antigen presentation abilities as an anti-cancer defense. Appearance of OGCs may not be anti-tumoural immunological reactions, but rather pro-tumoural differentiation of macrophage responding to hypervascular microenvironments induced by breast cancer.</p>http://www.diagnosticpathology.org/content/5/1/55 |
| spellingShingle | Shishido-Hara Yukiko Kurata Atsushi Fujiwara Masachika Itoh Hiroki Imoto Shigeru Kamma Hiroshi Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of macrophages? Diagnostic Pathology |
| title | Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of macrophages? |
| title_full | Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of macrophages? |
| title_fullStr | Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of macrophages? |
| title_full_unstemmed | Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of macrophages? |
| title_short | Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of macrophages? |
| title_sort | two cases of breast carcinoma with osteoclastic giant cells are the osteoclastic giant cells pro tumoural differentiation of macrophages |
| url | http://www.diagnosticpathology.org/content/5/1/55 |
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