Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells
Increasing evidence highlights that microRNAs (miRNAs) drive glioma initiation and development. Nevertheless, the underlying role of miR-21-5p in glioma is elusive. Hence, we evaluated the underlying role of miR-21-5p in glioma progression. Microarray data analysis provided data indicating that the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2021-10-01
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| Series: | Folia Neuropathologica |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Identification-of-miR-21-5p-TET1-negative-regulation-pair-in-the-aggressiveness-of-glioma-cells,20,45022,1,1.html |
| _version_ | 1818924729747111936 |
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| author | Zhuo Zhang Shu-Zhen Yang You-Fu Qi Yong Yin |
| author_facet | Zhuo Zhang Shu-Zhen Yang You-Fu Qi Yong Yin |
| author_sort | Zhuo Zhang |
| collection | DOAJ |
| description | Increasing evidence highlights that microRNAs (miRNAs) drive glioma initiation and development. Nevertheless, the underlying role of miR-21-5p in glioma is elusive. Hence, we evaluated the underlying role of miR-21-5p in glioma progression. Microarray data analysis provided data indicating that the miR-21-5p level was elevated in glioma. Silenced miR-21-5p suppressed glioma cell growth and invasion. Additionally, our results disclosed that ten-eleven translocation 1 (TET1) was directly targeted by miR-21-5p. Furthermore, antagomir-21-5p restrained glioma cell growth in a xenograft tumour model. In rescue experiments, knockdown of TET1 neutralized miR-21-5p silence-mediated inhibitory function on glioma cell aggressiveness. Taken together, miR-21-5p exerted its carcinogenic effect in glioma cell growth and invasin by targeting TET1. |
| first_indexed | 2024-12-20T02:29:58Z |
| format | Article |
| id | doaj.art-3b26fe3c69de47aea2666d4717653e0f |
| institution | Directory Open Access Journal |
| issn | 1641-4640 1509-572X |
| language | English |
| last_indexed | 2024-12-20T02:29:58Z |
| publishDate | 2021-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Folia Neuropathologica |
| spelling | doaj.art-3b26fe3c69de47aea2666d4717653e0f2022-12-21T19:56:36ZengTermedia Publishing HouseFolia Neuropathologica1641-46401509-572X2021-10-0159323924810.5114/fn.2021.10869545022Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cellsZhuo ZhangShu-Zhen YangYou-Fu QiYong YinIncreasing evidence highlights that microRNAs (miRNAs) drive glioma initiation and development. Nevertheless, the underlying role of miR-21-5p in glioma is elusive. Hence, we evaluated the underlying role of miR-21-5p in glioma progression. Microarray data analysis provided data indicating that the miR-21-5p level was elevated in glioma. Silenced miR-21-5p suppressed glioma cell growth and invasion. Additionally, our results disclosed that ten-eleven translocation 1 (TET1) was directly targeted by miR-21-5p. Furthermore, antagomir-21-5p restrained glioma cell growth in a xenograft tumour model. In rescue experiments, knockdown of TET1 neutralized miR-21-5p silence-mediated inhibitory function on glioma cell aggressiveness. Taken together, miR-21-5p exerted its carcinogenic effect in glioma cell growth and invasin by targeting TET1.https://www.termedia.pl/Identification-of-miR-21-5p-TET1-negative-regulation-pair-in-the-aggressiveness-of-glioma-cells,20,45022,1,1.htmlglioma proliferation invasion mir-21-5p tet1. |
| spellingShingle | Zhuo Zhang Shu-Zhen Yang You-Fu Qi Yong Yin Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells Folia Neuropathologica glioma proliferation invasion mir-21-5p tet1. |
| title | Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells |
| title_full | Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells |
| title_fullStr | Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells |
| title_full_unstemmed | Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells |
| title_short | Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells |
| title_sort | identification of mir 21 5p tet1 negative regulation pair in the aggressiveness of glioma cells |
| topic | glioma proliferation invasion mir-21-5p tet1. |
| url | https://www.termedia.pl/Identification-of-miR-21-5p-TET1-negative-regulation-pair-in-the-aggressiveness-of-glioma-cells,20,45022,1,1.html |
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