UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration

UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration

Interrupted axons that fail to regenerate mainly cause poor recovery after spinal cord injury (SCI). How neurons epigenetically respond to injury determines the intrinsic growth ability of axons. However, the mechanism underlying epigenetic regulation of axonal regeneration post-SCI remains largely...

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Bibliographic Details
Main Authors: Zhu Guo, Chengjun Li, Yong Cao, Tian Qin, Liyuan Jiang, Yan Xu, Miao Li, Zixiang Luo, Jianzhong Hu, Hongbin Lu
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
UTX
spinal cord injury
epigenetic regulation
microRNA-24
NeuroD1
microtubule stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120302527

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