Lymphatics and Lymphangiogenesis in the Eye
Lymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation. The eye was thought to lack lymphatic vessels except...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2012-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/783163 |
| _version_ | 1798045567934267392 |
|---|---|
| author | Shintaro Nakao Ali Hafezi-Moghadam Tatsuro Ishibashi |
| author_facet | Shintaro Nakao Ali Hafezi-Moghadam Tatsuro Ishibashi |
| author_sort | Shintaro Nakao |
| collection | DOAJ |
| description | Lymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation. The eye was thought to lack lymphatic vessels except for the conjunctiva; however, advances in the field, including the identification of lymphatic endothelial markers (e.g., LYVE-1 or podoplanin) and lymphangiogenic factors (e.g., VEGF-C), have revealed the exsitence and possible roles of lymphatics and lymphangiogenesis in the eye. Recent studies have shown that corneal limbus, ciliary body, lacrimal gland, orbital meninges, and extraocular muscles contain lymphatic vessels and that the choroid might have a lymphatic-like system. There is no known lymphatic outflow from the eye. However, several lymphatic channels including uveolymphatic pathway might serve the ocular fluid homeostasis. Furthermore, lymphangiogenesis plays important roles in pathological conditions in the eye including corneal transplant rejection and ocular tumor progression. Yet, the role of lymphangiogenesis in most eye diseases, especially inflammatory disease or edema, remains unknown. A better understanding of lymphatic and lymphangiogenesis in the eye will open new therapeutic opportunities to prevent vision loss in ocular diseases. |
| first_indexed | 2024-04-11T23:23:04Z |
| format | Article |
| id | doaj.art-3b296ad746e94a30ae2861e390bcbfb8 |
| institution | Directory Open Access Journal |
| issn | 2090-004X 2090-0058 |
| language | English |
| last_indexed | 2024-04-11T23:23:04Z |
| publishDate | 2012-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-3b296ad746e94a30ae2861e390bcbfb82022-12-22T03:57:23ZengHindawi LimitedJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/783163783163Lymphatics and Lymphangiogenesis in the EyeShintaro Nakao0Ali Hafezi-Moghadam1Tatsuro Ishibashi2Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanFunctional and Molecular Imaging Center and Department of Radiology, Brigham and Womenʼs Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanLymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation. The eye was thought to lack lymphatic vessels except for the conjunctiva; however, advances in the field, including the identification of lymphatic endothelial markers (e.g., LYVE-1 or podoplanin) and lymphangiogenic factors (e.g., VEGF-C), have revealed the exsitence and possible roles of lymphatics and lymphangiogenesis in the eye. Recent studies have shown that corneal limbus, ciliary body, lacrimal gland, orbital meninges, and extraocular muscles contain lymphatic vessels and that the choroid might have a lymphatic-like system. There is no known lymphatic outflow from the eye. However, several lymphatic channels including uveolymphatic pathway might serve the ocular fluid homeostasis. Furthermore, lymphangiogenesis plays important roles in pathological conditions in the eye including corneal transplant rejection and ocular tumor progression. Yet, the role of lymphangiogenesis in most eye diseases, especially inflammatory disease or edema, remains unknown. A better understanding of lymphatic and lymphangiogenesis in the eye will open new therapeutic opportunities to prevent vision loss in ocular diseases.http://dx.doi.org/10.1155/2012/783163 |
| spellingShingle | Shintaro Nakao Ali Hafezi-Moghadam Tatsuro Ishibashi Lymphatics and Lymphangiogenesis in the Eye Journal of Ophthalmology |
| title | Lymphatics and Lymphangiogenesis in the Eye |
| title_full | Lymphatics and Lymphangiogenesis in the Eye |
| title_fullStr | Lymphatics and Lymphangiogenesis in the Eye |
| title_full_unstemmed | Lymphatics and Lymphangiogenesis in the Eye |
| title_short | Lymphatics and Lymphangiogenesis in the Eye |
| title_sort | lymphatics and lymphangiogenesis in the eye |
| url | http://dx.doi.org/10.1155/2012/783163 |
| work_keys_str_mv | AT shintaronakao lymphaticsandlymphangiogenesisintheeye AT alihafezimoghadam lymphaticsandlymphangiogenesisintheeye AT tatsuroishibashi lymphaticsandlymphangiogenesisintheeye |