TRPV4 functional status in cystic cells regulates cystogenesis in autosomal recessive polycystic kidney disease during variations in dietary potassium

TRPV4 functional status in cystic cells regulates cystogenesis in autosomal recessive polycystic kidney disease during variations in dietary potassium

Abstract Mechanosensitive TRPV4 channel plays a dominant role in maintaining [Ca2+]i homeostasis and flow‐sensitive [Ca2+]i signaling in the renal tubule. Polycystic kidney disease (PKD) manifests as progressive cyst growth due to cAMP‐dependent fluid secretion along with deficient mechanosensitivit...

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Bibliographic Details
Main Authors: Kyrylo Pyrshev, Anna Stavniichuk, Viktor N. Tomilin, Naghmeh Hassanzadeh Khayyat, Guohui Ren, Mariya Kordysh, Oleg Zaika, Mykola Mamenko, Oleh Pochynyuk
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Physiological Reports
Subjects:
[Ca2+]i signaling
cAMP
mechanosensitivity
PCK453 rats
renal injury
Online Access:https://doi.org/10.14814/phy2.15641

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