Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening
Pioneer transcription factor Pax7 specifies melanotrope cells, which then allows for the binding of Tpit transcription factor. Here, authors find that while binding of heterochromatin targeting by Pax7 is independent of Tpit, Pax7-dependent chromatin opening requires Tpit.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11791-9 |
| _version_ | 1818681823260049408 |
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| author | Alexandre Mayran Kevin Sochodolsky Konstantin Khetchoumian Juliette Harris Yves Gauthier Amandine Bemmo Aurelio Balsalobre Jacques Drouin |
| author_facet | Alexandre Mayran Kevin Sochodolsky Konstantin Khetchoumian Juliette Harris Yves Gauthier Amandine Bemmo Aurelio Balsalobre Jacques Drouin |
| author_sort | Alexandre Mayran |
| collection | DOAJ |
| description | Pioneer transcription factor Pax7 specifies melanotrope cells, which then allows for the binding of Tpit transcription factor. Here, authors find that while binding of heterochromatin targeting by Pax7 is independent of Tpit, Pax7-dependent chromatin opening requires Tpit. |
| first_indexed | 2024-12-17T10:09:04Z |
| format | Article |
| id | doaj.art-3b2a61a2cc2044b9be570ebc3124d40d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:09:04Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3b2a61a2cc2044b9be570ebc3124d40d2022-12-21T21:53:06ZengNature PortfolioNature Communications2041-17232019-08-0110111310.1038/s41467-019-11791-9Pioneer and nonpioneer factor cooperation drives lineage specific chromatin openingAlexandre Mayran0Kevin Sochodolsky1Konstantin Khetchoumian2Juliette Harris3Yves Gauthier4Amandine Bemmo5Aurelio Balsalobre6Jacques Drouin7Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM)Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM)Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM)Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM)Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM)Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM)Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM)Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM)Pioneer transcription factor Pax7 specifies melanotrope cells, which then allows for the binding of Tpit transcription factor. Here, authors find that while binding of heterochromatin targeting by Pax7 is independent of Tpit, Pax7-dependent chromatin opening requires Tpit.https://doi.org/10.1038/s41467-019-11791-9 |
| spellingShingle | Alexandre Mayran Kevin Sochodolsky Konstantin Khetchoumian Juliette Harris Yves Gauthier Amandine Bemmo Aurelio Balsalobre Jacques Drouin Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening Nature Communications |
| title | Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening |
| title_full | Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening |
| title_fullStr | Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening |
| title_full_unstemmed | Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening |
| title_short | Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening |
| title_sort | pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening |
| url | https://doi.org/10.1038/s41467-019-11791-9 |
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