Prospective evaluation of hematological parameters in preoperative renal cell cancer patients
Abstract Background Of all the genitourinary cancers, renal cell carcinoma (RCC) is still the most common malignancy with high mortality rates. There are still insufficient biomarkers to predict disease prognosis. Systemic inflammation markers play an important role in tumor development and growth....
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Urology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12894-022-01118-0 |
| _version_ | 1811178979019718656 |
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| author | Ozden Demir Guzin Demirag Gokhan Aslan |
| author_facet | Ozden Demir Guzin Demirag Gokhan Aslan |
| author_sort | Ozden Demir |
| collection | DOAJ |
| description | Abstract Background Of all the genitourinary cancers, renal cell carcinoma (RCC) is still the most common malignancy with high mortality rates. There are still insufficient biomarkers to predict disease prognosis. Systemic inflammation markers play an important role in tumor development and growth. There are studies which show the relationship of fibrinogen and albumin individually with cancer prognosis in many cancers. Fibrinogen/albumin ratio(FAR), on the other hand, has prognostic importance like other inflammation indicators in cancer. Therefore, we investigated whether FAR had a potential value in evaluating the prognosis of patients with nonmetastatic kidney cancer or not. Methods A total of 72 patients who had nephrectomy operation at 19 Mayıs University, Faculty of Medicine between January 2019 and January 2021 and who did not have distant metastasis were included in the study. FAR was calculated from the blood taken from the patients before the nephrectomy operation. The cut-off value was found for this FAR by receiver operating characteristic(ROC) curve analysis. The patients were divided into 2 groups as high- and low-FAR according to this cut-off value. Kaplan Meier test was used to evaluate the predictive value of clinicopathological parameters for overall survival (OS). The Log-rank test was used to determine whether there was a relationship between the preoperative FAR and the clinico-pathological data of the patients. Results The best cutoff value for the FAR was 0.114. A FAR > 0.114 was associated with higher Fuhrman Grade (FG) (P < 0.0001) and later pathological T stage (P < 0.0001). Patients with a high FAR (> 0.114) had worse OS [Std. Error 2.932, 95% confidence interval (CI): 73.659–85.154, P < 0.0001]. In addition, a positive significant correlation was found between high grade and platelet lymphocyte ratio (p < 0,020). Furthermore, a significant correlation was found between the pathology t stage of the patients and the platelet lymphocyte ratio (p: 0.020). Conclusions The preoperative FAR is an independent prognostic factor of OS in renal cancer patients. A FAR > 0.114 was significantly related to decreased survival in renal cancer patients. In addition, the platelet-lymphocyte ratio seems to be related to OS, as well as FAR. Further studies are required on this subject. |
| first_indexed | 2024-04-11T06:28:08Z |
| format | Article |
| id | doaj.art-3b2aaf7c13a4452eb28c2cd171286474 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-04-11T06:28:08Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-3b2aaf7c13a4452eb28c2cd1712864742022-12-22T04:40:16ZengBMCBMC Urology1471-24902022-12-012211710.1186/s12894-022-01118-0Prospective evaluation of hematological parameters in preoperative renal cell cancer patientsOzden Demir0Guzin Demirag1Gokhan Aslan2Faculty of Medicine, Department of Medical Oncology, Ondokuz Mayıs UniversityFaculty of Medicine, Department of Medical Oncology, Ondokuz Mayıs UniversityFaculty of Medicine, Department of Internal Medicine, Ondokuz Mayıs UniversityAbstract Background Of all the genitourinary cancers, renal cell carcinoma (RCC) is still the most common malignancy with high mortality rates. There are still insufficient biomarkers to predict disease prognosis. Systemic inflammation markers play an important role in tumor development and growth. There are studies which show the relationship of fibrinogen and albumin individually with cancer prognosis in many cancers. Fibrinogen/albumin ratio(FAR), on the other hand, has prognostic importance like other inflammation indicators in cancer. Therefore, we investigated whether FAR had a potential value in evaluating the prognosis of patients with nonmetastatic kidney cancer or not. Methods A total of 72 patients who had nephrectomy operation at 19 Mayıs University, Faculty of Medicine between January 2019 and January 2021 and who did not have distant metastasis were included in the study. FAR was calculated from the blood taken from the patients before the nephrectomy operation. The cut-off value was found for this FAR by receiver operating characteristic(ROC) curve analysis. The patients were divided into 2 groups as high- and low-FAR according to this cut-off value. Kaplan Meier test was used to evaluate the predictive value of clinicopathological parameters for overall survival (OS). The Log-rank test was used to determine whether there was a relationship between the preoperative FAR and the clinico-pathological data of the patients. Results The best cutoff value for the FAR was 0.114. A FAR > 0.114 was associated with higher Fuhrman Grade (FG) (P < 0.0001) and later pathological T stage (P < 0.0001). Patients with a high FAR (> 0.114) had worse OS [Std. Error 2.932, 95% confidence interval (CI): 73.659–85.154, P < 0.0001]. In addition, a positive significant correlation was found between high grade and platelet lymphocyte ratio (p < 0,020). Furthermore, a significant correlation was found between the pathology t stage of the patients and the platelet lymphocyte ratio (p: 0.020). Conclusions The preoperative FAR is an independent prognostic factor of OS in renal cancer patients. A FAR > 0.114 was significantly related to decreased survival in renal cancer patients. In addition, the platelet-lymphocyte ratio seems to be related to OS, as well as FAR. Further studies are required on this subject.https://doi.org/10.1186/s12894-022-01118-0Renal cell cancerFibrinogen to albumin ratioBiomarkersPrognostic factor |
| spellingShingle | Ozden Demir Guzin Demirag Gokhan Aslan Prospective evaluation of hematological parameters in preoperative renal cell cancer patients BMC Urology Renal cell cancer Fibrinogen to albumin ratio Biomarkers Prognostic factor |
| title | Prospective evaluation of hematological parameters in preoperative renal cell cancer patients |
| title_full | Prospective evaluation of hematological parameters in preoperative renal cell cancer patients |
| title_fullStr | Prospective evaluation of hematological parameters in preoperative renal cell cancer patients |
| title_full_unstemmed | Prospective evaluation of hematological parameters in preoperative renal cell cancer patients |
| title_short | Prospective evaluation of hematological parameters in preoperative renal cell cancer patients |
| title_sort | prospective evaluation of hematological parameters in preoperative renal cell cancer patients |
| topic | Renal cell cancer Fibrinogen to albumin ratio Biomarkers Prognostic factor |
| url | https://doi.org/10.1186/s12894-022-01118-0 |
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